Oxidative Stress Markers and Its Correlation with Aminotransferases in Hepatic Manifestation of Dengue Virus Infection
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 8
Abstract
Objective: To study the correlation between oxidative stress markers and Aminotransferases in patients of dengue fever with hepatic manifestations. Background: Manifestation of viral infection may be contributed by the alteration of oxidation/reduction (Redox) status in virus infected patients and this alteration starts prior to symptoms of disease appear. Increased level of Aminotransferases may be a useful marker of hepatic insult. Method: We conducted a cross sectional hospital based study of 90 patients serologically confirmed to have dengue virus infection who have hepatic manifestations. Blood samples were collected on 4th day and onwards after the fever and analysed for liver function tests (LFT), prothombin time (PT) and thrombocytes and other haematological parameters. And to measure the oxidative stress blood was analysed for malondihyde (MDA), catalase (CAT), glutathione peroxidase(GPx ) and paraoxanase(PON). Results: Among the LFT parameters the level of Aspartate transaminase (AST) was significantly raised followed by alanine transaminase (ALT) and other parameters were either within normal limit or not significant. The level of MDA was significantly raised and level of GPx , CAT and PON was reduced. The significant correlation was found between ALT, AST and oxidative stress markers. Conclusion: So we can conclude that in patients of dengue infection, raised liver enzyme (AST, ALT) may be associated with oxidative stress and AST can be used in a severity index and as prognostic marker in hepatic manifestations.
Authors and Affiliations
Sandeep Singh
Keywords
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