OXIDATIVE STRESS RESPONSIBLE FOR GENOTOXIC EFFECTS IN TYPE 2 DIABETES MELLITUS PATIENTS IN POPULATION OF WEST BENGAL
Journal Title: International Journal of Genetics - Year 2016, Vol 8, Issue 4
Abstract
Type 2 Diabetes mellitus (T2DM) is a chronic, debilitating disease affecting a significant proportion of the population and becoming an epidemic worldwide. Increasing evidence in both, experimental and clinical studies suggest oxidative stress (OS) plays a major role in the pathogenesis of both types of diabetes mellitus and its complications. The OS may exhibit chromosomal instability leading to chromosomal aberration frequencies. A case-control study of sixty-two patients with T2DM (n=62) and ten healthy control subjects (n=10) were screened from different areas of West Bengal. All procedures were done with the informed consent of participants. Blood cultures were done for analyzing chromosome aberrations as per routine procedures In the present study, increased chromosomal aberration frequencies and mitotic index were observed in T2DM patients that may be due to increased oxidative stress leading to different mechanisms like oxidative damage, repair mechanisms and resulting in genomic instability, which in turn may contribute to an increased risk for cancer. Therefore, this study will explore the role of oxidative stress for genomic instability and causing cancer.
Authors and Affiliations
PRIYANKA BISWAS, PRASANTA BHATTACHARYA, MADHUSNATA DE
Keywords
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