OXIDATIVE STRESS, SKIN AGING AND ANTIOXIDANT THERAPY
Journal Title: Acta Facultatis Medicae Naissensis - Year 2014, Vol 31, Issue 4
Abstract
Skin aging is a dynamic process that occurs due to chronological and photo-aging caused by the influence of external factors, especially ultraviolet-UV radiation. Cumulative oxidative stress, formation of free radicals and their adverse effects on biological systems in the skin cells is a common mechanism of both skin aging processes. The formed reactive oxygen species-ROS can lead to the oxidation of cell`s building molecules. Lipid peroxidation, membrane protein damage and DNA mutation may lead to many structural, functional and aesthetic changes in the skin and can also initiate development of many diseases. One of the skin defense mechanisms is antioxidant defense where enzymes and other antioxidant substances react directly with ROS, preventing them from reaching their biological target. Antioxidant substances have the ability to bind free radicals, caused by oxidative stress, and may have significance in prevention and/or therapy of various skin diseases, as well as in slowing the skin aging process. Topical application of antioxidants, such as vitamin C and E, coenzyme Q10 and polyphenolic compounds may provide the strengthening of the skin endogenous protection system and protection from harmful effects of ROS and oxidative damage to the skin. This article outlines the impact of oxidative stress on the chronological and photo-aging, its mechanism of action, the changes that occur on/in the skin during the aging process. Substances with antioxidant characteristics, which can be used in the prevention of chronological and/or treatment of photo-aging of the skin are shown.
Authors and Affiliations
Dragana Stojiljković, Dušica Pavlović, Ivana Arsić
Keywords
Related Articles
- EP ID EP163219
- DOI 10.2478/afmnai-2014-0026
- Views 92
- Downloads 0
Investigation of the Factors Affecting the Sexual Function in Women of Reproductive Age Referred to the Women's Clinic of Hakim Neyshabur Hospital in 2015, Iran
The aim of this study was to determine the factors affecting the sexual function of women of reproductive age with reference to the adverse effects of sexual dysfunction in women and its consequences on family life. This...
Učenje po modelu: dragoceno nasleđe u medicinskom obrazovanju
Učenje po modelu je vrlo efikasan način učenja i sastavni deo medicinske edukacije. Premda učenje po modelu ima dugu istoriju u medicinskoj edukaciji, još uvek mu se ne pridaje dovoljan značaj. Cilj ove studije bio je d...
Psychometric Development of Chemotherapy Side Effects Fear Scale - - - Izrada i ispitivanje pouzdanosti i validnosti upitnika za procenu nivoa straha bolesnika od neželjenih dejstava hemoterapije
Anxiety, depression and fear in general are the most common emotional problems in people with cancer and it is necessary to recognize them. The patients’ attitude towards the side effects of chemo-therapy has changed sig...
EARLY HEMATOPOIETIC CELL TRANSPLANTATION RESULTS IN HIGHER OVERALL SURVIVAL AND LEUKEMIA FREE SURVIVAL COMPARED TO CONVENTIONAL CHEMOTHERAPY IN HIGH RISK ACUTE MYELOID LEUKAEMIA (AML) PATIENTS
Between 1996 and 2004, a total of 708 patients were enrolled in the AML ´96 and 2002 studies of the East German Study Group. Of those, 138 patients (19.5%) had unfavourable cytogenetics defined as complex karyotype, del...
The Impact of Disease Activity in Patients with Rheumatoid Arthritis on Metabolic Syndrome and Cardiovascular Risk Assessment
Patients with rheumatoid arthritis (RA) have a 1.5 times higher cardiovascular disease mortality compared to the general population, while the life expectancy of these patients is 5-10 years shorter compared to the gener...