OXIDATIVE STRESS, SKIN AGING AND ANTIOXIDANT THERAPY
Journal Title: Acta Facultatis Medicae Naissensis - Year 2014, Vol 31, Issue 4
Abstract
Skin aging is a dynamic process that occurs due to chronological and photo-aging caused by the influence of external factors, especially ultraviolet-UV radiation. Cumulative oxidative stress, formation of free radicals and their adverse effects on biological systems in the skin cells is a common mechanism of both skin aging processes. The formed reactive oxygen species-ROS can lead to the oxidation of cell`s building molecules. Lipid peroxidation, membrane protein damage and DNA mutation may lead to many structural, functional and aesthetic changes in the skin and can also initiate development of many diseases. One of the skin defense mechanisms is antioxidant defense where enzymes and other antioxidant substances react directly with ROS, preventing them from reaching their biological target. Antioxidant substances have the ability to bind free radicals, caused by oxidative stress, and may have significance in prevention and/or therapy of various skin diseases, as well as in slowing the skin aging process. Topical application of antioxidants, such as vitamin C and E, coenzyme Q10 and polyphenolic compounds may provide the strengthening of the skin endogenous protection system and protection from harmful effects of ROS and oxidative damage to the skin. This article outlines the impact of oxidative stress on the chronological and photo-aging, its mechanism of action, the changes that occur on/in the skin during the aging process. Substances with antioxidant characteristics, which can be used in the prevention of chronological and/or treatment of photo-aging of the skin are shown.
Authors and Affiliations
Dragana Stojiljković, Dušica Pavlović, Ivana Arsić
Keywords
Related Articles
- EP ID EP163219
- DOI 10.2478/afmnai-2014-0026
- Views 97
- Downloads 0
ARONIA MELANOCARPA FILTER ČAJ: FENOLNI PROFIL I ANTIOKSIDATIVNA AKTIVNOST
U cilju dobijanja informacija o antioksidativnoj aktivnosti infuz čajeva ploda aronije (Aronia melanocarpa) određena je koncentracija pojedinačnih fenolnih jedinjenja za koje se smatra da su odgovorna za antioksidativnu...
SUBKONJUNKTIVALNA INFEKCIJA IZAZVANA DIROFILARIJOM REPENS - PRIKAZ SLUČAJA
Cilj ovog rada bio je da se predstavi klinički tok i hirurško lečenje prvog slučaja humane okularne dirofilariose na teritoriji grada Niša, u jugoistočnoj Srbiji. Muškarac, 57 godina starosti, obratio se oftalmologu zbog...
The Impact of Disease Activity in Patients with Rheumatoid Arthritis on Metabolic Syndrome and Cardiovascular Risk Assessment
Patients with rheumatoid arthritis (RA) have a 1.5 times higher cardiovascular disease mortality compared to the general population, while the life expectancy of these patients is 5-10 years shorter compared to the gener...
MATURE INTRACRANIAL TERATOMA
Teratomas constitute a group of nongerminomatous germ cell tumors that are composed of an admixture of different tissue types representative of ectoderm, endoderm and mesoderm. Intracranial teratomas are rare, comprising...
TREATMENT OF WAR TRAUMA FRACTURES OF THE PROXIMAL HUMERUS
A war wound to the proximal humerus is characterised by profuse bleeding, multifragmentary fracture-dislocations, defects of the muscle tissue, capsule, skin and by primary contamination with polymorphic bacterial flora,...