OXYTOCIN GIVEN AS IV BOLUS VERSUS IV INFUSION IN WOMEN UNDERGOING CAESAREAN SECTIONA RANDOMISED, CONTROLLED, DOUBLE-BLIND STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 11
Abstract
BACKGROUND Oxytocin is the uterotonic of choice in the prevention of uterine atony. It reduces blood loss during both vaginal deliveries(1) and caesarean sections. Its prophylactic and therapeutic administration is justified, because it is said to reduce the incidence of PPH by about 40%. However, bolus use of oxytocin is known to cause cardiovascular effects including tachycardia, hypotension and ST changes. Aims and Objectives- To compare the uterine tone, blood loss and haemodynamic responses on intravenous administration of oxytocin 5 units given as IV bolus or IV infusion in women undergoing Caesarean section under sub-arachnoid block. MATERIALS AND METHODS This is a randomised, controlled, double-blind study. 80 patients were allocated into two groups. Sample is considered conveniently1. Group I: To receive 5 units of oxytocin over 5 seconds (Bolus). 2. Group II: To receive 5 units of oxytocin in 15 mL NS over 5 minutes (Infusion). RESULTS Heart rate (beat/min) effect of oxytocin given intravenous bolus vs. infusion showed statistically significant difference from 1 minute to 5 minutes (p < 0.05). Similarly, mean arterial pressure (MAP) rate (beast/min) effect of oxytocin given intravenous bolus vs. infusion also showed statistically significant difference from 1 minute to 5 minutes (p < 0.05). CONCLUSION We recommend that bolus doses should be avoided or to be used with caution, and further studies should ascertain if oxytocin is equally effective in reducing blood loss when given at a slower rate
Authors and Affiliations
Ruchi Tandon, Tahir Ali Khan, Shikha Mehrotra
Keywords
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- EP ID EP411672
- DOI 10.14260/jemds/2018/323
- Views 89
- Downloads 0
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