P16INK4a An Independent Prognostic Marker in Head and Neck Squamous Cell Carcinomas
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 10
Abstract
Introduction/Background: The aim of the present study is to determine the expression of p16INK4a and its prognostic utility in the head and neck squamous cell carcinomas (HNSCC). Squamous cell carcinoma of the head and neck is a major public health problem in developing countries. A subset of head and neck cancer is associated with the human papillomavirus (HPV) [1]. Viral infection is closely correlated with expression of p16INK4a in these tumours. p16INK4a is the strongest independent prognostic marker in HNSCC and is associated with favourable prognosis [1]. Materials and Methods: The present study is retrospective study done during the period from June 2016 to July 2017. A total of 52 cases were taken and histological grading was done according to WHO criteria. p16INK4a expression was determined by immunohistochemical staining on the paraffin embedded tissue sections. Results: Out of 52 cases, 41/52 cases (78.8%) were positive for p16INK4a and remaining 11/52 cases (21.2%) were negative for p16INK4a. Expression of p16INK4a was graded accordingly. Conclusion: p16INK4a is an independent prognostic marker for HNSCC. p16 protein overexpression is very sensitive for the presence of transcriptionally active HPV and is widely available and also easy to interpret the test result. Expression of p16INK4a has major impact on treatment response and survival in patients with HNSCC.
Authors and Affiliations
P. Vidyadhara Rani
Keywords
Related Articles
- EP ID EP529780
- DOI 10.21088/ijprp.2278.148X.71018.5
- Views 57
- Downloads 0
Utility of Bone Marrow Aspiration and Bone Marrow Biopsy in Haematological Disorders
Background: Bone marrow aspiration (BMA) and Bone marrow biopsy (BMB) are very useful procedures for the diagnosis of haematological and non haematological malignancies, typing of anemia, pyrexia of unknown origin and in...
Clinicopathological Analysis of Malignant Tumours of the Sinonasal Tract
Background: The nasal cavity and the paranasal sinuses form a single functional unit. Malignant sinonasal tumours are characterized by low incidence, non specific symptoms, and late presentation. The malignant sinonasal...
Ovarian Tumors Analysis with Emphasis on Teratoma (4 yrs at Tertiary Care Center in Rural India)
Introduction: Teratoma are most common germ cell tumor of the ovary. There are various histological types of teratoma and clinically they present with various behavior. The aim of this study is to determine the various m...
The Bethesda System for Reporting Thyroid Cytopathology with Histological Correlation
Background and Objectives: The Bethesda system for reporting thyroid cytopathology (TBSRTC) is a standard method for analyzing thyroid smears, there by communicating clear and relevant information to the clinician. Objec...
Study of Diagnostic Efficacy of the Fine Needle Aspiration Cytology of Lymphadenopathy as Compared to Open Biopsy for Histopathological Examination
Background: Lymphadenopathy is an abnormal increase in size and/ or altered consistency of lymph nodes. It is a very common clinical manifestation of regional or systemic disease caused by the invasion or propagation of...