p53 Expression Activation of HIV-1 Latency in U1 Cells
Journal Title: International Journal of Virology and AIDS - Year 2017, Vol 4, Issue 1
Abstract
Latent infection is a major barrier for cure of HIV-1 infection. HIV-1 is capable of establishing latency when its host cells undergo apoptosis and initiate replication in response to this effect. HIV infection results in increased p53 expression that enhances replication in primary infection. To examine whether p53 reactivates HIV-1 replication from latent infection, we used susceptible U1 cells chronically infected with HIV-1 to study the effects of p53 on reactivation of HIV-1 replication in the monocyte/macrophage cell reservoir.
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- EP ID EP354741
- DOI 10.23937/2469-567X/1510036
- Views 94
- Downloads 0
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