Paget’s Disease Of The Spine With Low Bone Alkaline Phosphatase
Journal Title: Journal of Neurological Sciences-Turkish - Year 2005, Vol 22, Issue 2
Abstract
We present a case of 35-year-old man who was referred to us with a preliminary diagnosis of multiple spinal metastasis. Laboratory studies have shown a high serum alkaline phosphatase and a low bone alkaline phosphatase levels. Spinal magnetic resonance scans demonstrated involvement of T9, T11 and L3 vertebral bodies. The involved vertebrae appeared hypointense on T1- and hyperintense on T2-weighted images and a radionuclide bone scan has shown increased uptake in involved vertebral bodies. A transpedicular open biopsy was considered necessary for accurate diagnosis. Histopathologic evaluation of the specimen revealed typical “mosaic pattern” of Paget’s disease. After surgery, urinary deoxypridinoline and pridinoline levels were tested and were higher than normal. The patient was given oral doses of alendronate, 40 mg per day and follow-up magnetic resonance scans at 6 months and 2 years demonstrated improvement in the signal intensity of the involved vertebral bodies. This case not only shows that Paget’s disease can occur in the setting of low bone AP but also shows that the clinical improvement can be monitored by improvement in magnetic resonance signal
Authors and Affiliations
Ferda CAGAVI, Ismail TEKKOK, Gokhan AKPINAR, Yucel GUNGEN
Keywords
Related Articles
- EP ID EP107570
- DOI -
- Views 87
- Downloads 0
Determination of Functional Regions of Human DAT For Labeling With Fluorescent Proteins For Further Use in FRET Studies
The dopamine transporter tightly regulates dopamine neurotransmission by the rapid uptake of released dopamine back into the presynaptic nerve terminal. This study aimed to determine functional positions for eCFP inserti...
A Case Of Acute Akinetic Rigid Parkinsonism Due To Honeybee Sting
The clinical manifestations of honeybee sting are myriad. Although most such stings are followed by local allergic reactions only but it can be potentially serious. The rare manifestations comprise of encephalitis, acute...
Multipl Sklerozda Kısa Süreli Yüksek Doz Puls Kortikoterapinin Kemik Mineral Yoğunluğu Üzerine Etkisinin Değerlendirilmesi
Amaç: Osteoporoz uzun süreli kortikosteroid kullanımının en sık yan etkilerinden biridir. Multipl skleroz hastalarına hayatlarının belirli dönemlerinde atak tedavisi olarak kısa süreli yüksek doz puls metilprednizolon uy...
Plexiform Neurofibroma of Scalp in a Child: A Case Report
Epicranial neurofibromatosis is a rare diagnosis in Neurofibromatosis patients, frequently seen in the occipital region, which can be the cause of bone destruction. Although plexiform neurofibromas are congenital lesions...
İnme Sonrası Geç Başlangıçlı Nöbetler
İleri yaşta ortaya çıkan nöbetlerin en sık nedeni serebrovasküler hastalıklardır. İnmeden iki hafta sonra ortaya çıkan nöbetler, geç başlangıçlı nöbetler olarak adlandırılmaktadır. Geç başlangıçlı nöbetler, erken nöbetle...