Paraoxonase and Prolidase Activity in Patients With Malignant Gliomas
Journal Title: Journal of Neurological Sciences-Turkish - Year 2012, Vol 29, Issue 4
Abstract
Aim: We aimed to determine the relationship both paraoxonase and prolidase activitys in the patients with malignant glioma. Methods: In this study, serum paraoxonase and prolidase activitys were measured on 25 healthy human and 25 patients with malignant glioma. Paraoxonase activity was measured using diethyl-p-nitrophenylphosphate as substrate, as previously described. The prolidase activity was used for measurement of proline by the method proposed by Myara et al., which is a modification of Chinard's method (Myara et al.,1982). Results: The paraoxonase and prolidase activitys were significantly lower in serum of patients with malignant glioma as a whole compared to controls. Conclusions: In the current study, the activity paraoxonase and prolidase decreased in the patients with malignant glioma. As a result the paraoxonase and prolidase decreased seems to play a major role in the pathophysiology of malignant glioma. This is the first report on serum paraoxonase and prolidase decreased activities in patients with malignant gliomas.
Authors and Affiliations
Edip GONULLU, Gökalp SILAV, Miktat KAYA, Mehmet ARSLAN, Hayriye GONULLU, Harun ARSLAN, Aysegul CEBI, Halit DEMIR
Keywords
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