Partial Segmental Testicular Infarction in a Mature Rhesus Macaque (Macaca mulatta) Resembling a Human Condition
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2017, Vol 1, Issue 3
Abstract
This paper describes a case of segmental testicular infarction (STI), a rarely described human condition resulting from partial ischemia of the testis and often resulting from complex, organic, traumatic or metabolic causes, although an idiopathic etiology has been also considered. Being an important human occurrence, STI has not been reported in non-human primates (NHP) and this work is aimed to characterize a fortuitous case of STI in a 20-year-old male rhesus macaque, demonstrated by clinical findings, ultrasonography and histopathology studies. Clinically, the subject presented a significant scrotal wall thickening and in duration of the right testis palpated at its lower pole, while ultrasonography revealed a hypoechoic irregular mass of poorly defined margins. Upon excising this organ, the histological findings demonstrated a well-defined hemorrhagic nodule measuring 1 cm in diameter consistent with segmental testicular infarction, confirmed by further detailed observations disclosing arteriolar wall thickening and a double lumen, indicating post-infarctrecanalization considered an analogous condition seen in human stroke.Segmental testicular infarction (STI) is a rarity, and when diagnosed in humans it occurs as result of partial ischemia [1] or complex organic, traumatic [2] or other metabolic causes [3-6], although an idiopathic etiology has been also considered [7,8]. Other etiologic factors leading to STI have been reported, such as sickle cell anemia [9], vasculitis [10], acute epididymo-orchitis, epididymitis [8,11], torsion of testicular appendage, incarcerated hernia and trauma [1,12]or have included iatrogenic vascular injury [11,13], although sound reports suggests that it may also occur after spontaneous infection or surgery [2]. Another striking mechanism recently studied is cholesterol embolism-associated STI [3], which particularly affects males between their second and fourth decade of life [8]. In our description, a vast literature review showed that no previous reports of STI have been published in animal models such as non-human primates (NHP), and hence the purpose of this paper is to report the diagnosis and characterization of a fortuitous case of STI diagnosed in a 20-year-old male rhesus macaque, who´s lesion strongly resembled are human disease.
Authors and Affiliations
Eduardo Tena-Betancourt, Braulio Hernandez-Godinez, Salvador A Solis-Chavez, Yessica Heras-Romero, Alberto Aranda-Fraustro, Alejandra Ibáñez-Contreras
Keywords
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- EP ID EP572772
- DOI 10.26717/BJSTR.2017.01.000315
- Views 157
- Downloads 0
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