Pathogenesis of Cerebrovascular Malformations and Anti-Ki-67 (MIB-1) Proliferating Index
Journal Title: Journal of Neurological Sciences-Turkish - Year 2005, Vol 22, Issue 3
Abstract
The pathogenesis of cerebrovascular malformations is currently unknown. Lately recent researchs suggest that their pathogenesis and development might be due to a series of factors taking part in angiogenesis. Angiogenic growth factors including vascular endothelial growth factor, proliferating nuclear cell antigen, Ki-67, vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR) Flk-1 have been demonstrated in cerebrovascular malformations. Until now, in the relevant literature only two studies about anti-Ki-67 proliferating index (MIB-1) at cavernous hemangioma (CH) have been cited. However, these particular articles had no word on Ki-67 reactivity of endothelials cells in cavernous hemangioma. The mainstay of this study is definition of Ki-67 and p53 reactivity in cavernous hemangioma (CH), arteriovenous malformations (AVM) and capillary telangiectasia (CT). Paraffin embedded sections stained immunohistochemically with antibodies to Ki-67 and P53 in selected cases representing CH (n=14), AVM (n=11) and CT (n=2) were analyzed. Labeling indices for Ki-67 were found to be immunopositively reacting in endothelial cells of 5 cases of CH (45%) and 7 cases of AVM(50%). This findings emphasizes a remarklably higher ratio of proliferating cell pool in AVM than that of CH cases. From the point of understanding importance and impact of proliferating cell population in pathogenesis, a systematic investigation using a wide battery of antibodies for other molecular angiogenic factors should be applied for better understanding of these curious entities.
Authors and Affiliations
Ahmet MIDI, Aydin SAV, Turker KILIC, Necmettin PAMIR
Keywords
Related Articles
- EP ID EP154776
- DOI -
- Views 96
- Downloads 0
The Effect of Temozolomide Dose and Erythropoietin Combination On Survivin Gene Expression in Human Glioblastoma Cell Lines
Glioblastoma (GBM) is an aggressive primary brain tumor and it is known that prognosis is poor. Because of the infiltration of the tumor cells to the whole brain tissue, surgery is done for decompression and for histopat...
Prognosis and Clinical Features of Idiopathic Generalised Epilepsy Patients Older Than 40 Years
Introduction: Idiopathic generalised epilepsies (IGE) are usually seen in the first two decades of life. There is a paucity of data of these patients when they get older. Methods: Patients admitted to our epilepsy cente...
Beyin tumorleri tedavisinde yeni perspektifler
Beyin tümörlerinin tedavisinde nöroşirürjideki gelişmelere paralel olarak son yirmi yıl içinde belirgin bir ilerleme sağlandığını söyleyebiliriz. Benim ihtisas yaptığım 1980 yılından bir kesit aldığımızda; örneğin BT, pt...
Temporosphenoidal Fibrous Dysplasia: A Case Report
Fibrous dysplasia (FD) is a localized disorder of bone that may lead to bony distortional expansions. We report a case of FD of the temporosphenoidal bone. In this case, we took out subtotally the part of the temporal bo...
The Effect of Unilateral Visual Neglect on Mobility Status and Quality of Life in Stroke Patients
Aim: Unilateral Visual Neglect (UVN) in stroke patients refers not to respond or orient to a visual stimuli appearing on the side contralateral to the lesion. The purpose of this study was to explore the effect of the UV...