Pattern of adverse drug reactions in rural tertiary care medical college and hospital of Himachal Pradesh: A retrospective observational study
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2018, Vol 5, Issue 1
Abstract
Introduction Adverse events can lead to admission in hospital prolongation of hospitalization increase in investigations as well as treatment costs deformities danger to life and even deathObjective The aim of this study was to conduct adverse drug reactions ADRs monitoring in various departments of a tertiary care teaching hospitalMethods A retrospective observational study was conducted on ADRs reported in adverse drug monitoring center of our hospital from April 2016 to December 2016 Data such as age gender diagnosis drug intake types of ADRs treatment and outcome of the reactions were collected Each reported patient was assessed individually Causality assessment was done on Naranjorsquos probability scale Modified Hartwigrsquos criteria were used to assess the severity of ADRsResults A total of 173reports were studied 6538 patients were males and 108 62 were females The majority of ADRs were due to cancer chemotherapy agents in 8750 followed by antitubercular drugs in 2213 antimicrobial agents in 22 13 and antiretroviral drugs in 169Out of total 574 events 19234complaints comprised of gastrointestinal manifestations On Naranjorsquos probability scale 11164 reactions were probable 54 31 as possible and 8 5 as certain According to Modified Hartwigrsquos criteria 130 75 reactions were mild 29 17 were moderate and 148 were severeConclusion Healthcare providers will have to do vigilant monitoring and reporting of ADRacutesKeywords Pharmacovigilance Adverse drug reactions Chemotherapy Causality assessment Tertiary care teaching hospital
Authors and Affiliations
Himani Prajapati, Dinesh Kansal, Usha K. Chaudhary
Keywords
Related Articles
- EP ID EP478529
- DOI 10.18231/2393-9087.2018.0002
- Views 86
- Downloads 0
Anti-Cancer potentials of the plant Aquilaria malaccensis leaves
In the present study the ethanolic extract of Aquilaria malaccensis Agar wood leaves before inoculation BF and after inoculation AF was evaluated for its anticancer potentials The leaf extracts BF and AF was subjected to...
Effect of papaya leaves (Carica Papaya) suspension on Japanese quail (coturnix Japonica)
Introduction The experiment was aimed to investigate i the comparative efficacy of papaya leaves suspension PLS and doxycycline on bacterial load and blood constituents on E coli inoculated Japanese quail ii the effect o...
To compare the safety and efficacy of diacerein and oxaceprol in the management of grade I & II osteoarthritis of knee
Introduction Diacerein and oxaceprol are frequently used for the treatment of GradeI II osteoarthritis of knees Diacerein acts by blocking the action of interleukin1 whereas oxaceprol prevents leukocyte infiltration in...
Optimization and study of variables in microwave assisted organic synthesis of some biologically active chalcones
Chalcones are α,β-unsaturated ketone compounds, constituting an important class of natural products belonging to the flavonoid family. They have been reported to possess a wide spectrum of biological activities, includin...
Assessment of Knowledge, Attitude and Practice of Self-medication among Second Year MBBS Students
Introduction: The objective of this study was to elicit the self-medication patterns in second year medical students and to assess whether medical training results in any change. Methods: This was a cross-sectional study...