PATTERN OF LUNG CANCER METASTASIS BASED ON PET CT
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 51
Abstract
BACKGROUND Accurate staging is the cornerstone in management of lung cancer. It helps to determine the therapeutic modality and to assess prognosis. More than half of bronchogenic carcinomas have distant metastasis at the time of diagnosis. Presence of metastasis confers stage 4 for the disease. Presence of metastasis also increases patient morbidity and mortality. So the knowledge of pattern and sites of metastasis in bronchogenic carcinoma is crucial for its detection and management. Staging of bronchogenic carcinoma is one of the important indications for Positron Emission Tomography. Combined Computed tomography and PET (PET-CT) is superior to either modality alone in staging of lung cancer. It helps in identifying the site and morphology of lesion. Aims and Objectives- 1. To determine the sites of metastases in Bronchogenic carcinoma by PETCT 2. To compare sites of metastases with the histological cell type MATERIALS AND METHODS It was a hospital based retrospective study involving 78 patients with histologically proven bronchogenic carcinoma who underwent PETCT scan from June 2016-May 2017 in A J Institute of medical sciences, Mangalore. The sites of metastasis were noted. Brain metastasis was not included as MRI is a more sensitive tool. The sites of metastases as determined by PETCT were compared with histological cell type of bronchogenic carcinoma. RESULTS There were a total of 78 patients 61 male and 17 females. Majority of them were adenocarcinoma, followed by squamous cell carcinoma 38.5% and small cell carcinoma 9%. Majority had lymph node metastasis to supraclavicular nodes (61.53%) followed by contralateral lung (51.28%), bone metastasis (48.71%), abdominal nodes (28.21%), pleural metastasis (25.64%), adrenals (23.1%), Liver (20.51%), pericardial effusion (3.84%), spleen (2.56%). Among cases of adenocarcinoma 65.85% had metastasis to supraclavicular nodes, 56.09% had metastasis to contralateral lung, followed by bone metastasis (53.65%). Among patients with squamous cell carcinoma, majority ie, 53.33% had metastasis to contralateral lung, 40% had bone metastasis. CONCLUSION 1. Most common site of metastasis in bronchogenic carcinoma is supraclavicular nodes. 2. Most common organ of metastasis is contralateral lung followed by bone. 3. Commonest extra nodal site of metastasis is contralateral lung for both adenocarcinoma and squamous cell carcinoma.
Authors and Affiliations
Harsha D. S, Vishnu Sharma Moleyar, Alka Chaitra Bhat, Mithuneshwar Reddy Konda, Abhishek Bali, Abdu Rahiman Erinhikath Ummer
Keywords
Related Articles
- EP ID EP220247
- DOI 10.18410/jebmh/2017/617
- Views 94
- Downloads 0
SILICONE TUBE INTUBATION IN ADULTS WITH NASOLACRIMAL DUCT OBSTRUCTION AND IN CHILDREN WITH FAILED PROBING
BACKGROUND Nasolacrimal duct obstruction will lead onto dacryocystitis. This may occur in neonates and children and also. In adults it usually has a chronic course which may end in procedures like Dacryocystorhinostomy (...
EVALUATION OF LOWER GASTROINTESTINAL BLEEDING WITH SPECIAL REFERENCE TO COLONOSCOPY
BACKGROUND We wanted to evaluate the aetiology, age incidence, histopathology, site of occurrence of lower gastrointestinal bleeding using colonoscope. We also wanted to study the clinical presentations of different type...
A RARE CASE OF OVARIAN TERRATOMA CAUSING ACUTE AUTOIMMUNE ENCEPHALITIS
Anti-NMDA (N-methyl D-aspartate) receptor antibody encephalitis, also termed NMDA receptor antibody encephalitis, is an acute form of encephalitis caused by an autoimmune reaction primarily against the NR1 subunit of the...
MINOR PHYSICAL ANOMALIES IN POSITIVE VERSUS NEGATIVE SYMPTOMS PATIENTS OF SCHIZOPHRENIA
BACKGROUND The term ‘Minor Physical Anomalies (MPAs)’ has been described by Jones (1988)78 as “unusual morphologic features that are of no serious medical or cosmetic consequences to the patient. The value of their diagn...
MULTIPLE MYELOMA- ANALYSIS OF DIAGNOSTIC CRITERIA AND PROGNOSTIC FACTORS
BACKGROUND Multiple myeloma is a plasma cell neoplasm that accounts for about 10% of haematological malignancies. It is characterised by a single clone of plasma cells producing a monoclonal protein (M protein), which re...