PCL/PEG coaxially spun fibers as a drug delivery system for anti-thrombotic pharmaceutical agents
Journal Title: Scholars Academic Journal of Biosciences - Year 2016, Vol 4, Issue 2
Abstract
Abstract: Electrospinning is an effective technique to prepare non-woven fibrous formulations with interesting properties that enable the encapsulation of various pharmaceutical agents. Targeted delivery of drugs, while preventing any side effects or toxicity, still remains a challenge, especially in the cardiovascular field and therefore, nano/ sub-micron fibers created by electrospinning have been investigated as drug delivery system (DDS) candidates. The aim of the current study was to create coaxially spun fibers and investigate their morphological and biological characteristics, as well as, the release kinetics of the encapsulated pharmaceutical agent. Dipyridamole (DIP), polycaprolactone (PCL), and polyethylene glycol (PEG) were dissolved in 2,2,2-trifluoroethanol (TFE). DIP was chosen as a model anti-thrombotic agent that could be used in cardiovascular diseases to prevent thrombosis. The structural properties of the fibers were assessed with scanning electron microscopy (SEM). The cumulative release of DIP was assessed by UV-vis spectrometry using standard curves of absorbance versus concentration. Biocompatibility experiments were conducted using murine L-929 fibroblasts (Passage 7). Smooth, cylindrical sub-micron fibers were fabricated, providing a sustained bi-phasic release kinetics profile of DIP during an extended period of more than 3 months with an initial burst phenomenon during the first 8h and a subsequent gradual diffusion through the polymeric matrix. No change in the metabolic activity of the fibroblasts in the presence of the fibers extracts was observed from the cytotoxicity assay. In a nutshell, coaxially electrospun fibers exhibited some interesting features, indicating their potential as DDS candidates. Keywords: Dipyridamole, drug delivery system, electrospinning, fibers, polyethylene glycol, polycaprolactone.
Authors and Affiliations
Alexandros Repanas, Fedaa AL Halabi, Sofia Andriopoulou, Sotirios Korossis, Birgit Glasmacher
Keywords
Related Articles
- EP ID EP372064
- DOI -
- Views 95
- Downloads 0
Prevalence of Undiagnosed Glaucoma in Type 2 Diabetics Attending Outpatient Department at Regional Institute of Ophthalmology, Amritsar-A Hospital Based Study
Abstract: Diabetes and glaucoma share common pathophysiology and diabetes increase the risk of developing glaucoma. However the significance and impact of thorough eye examination for glaucoma in all diabetics is not cle...
Knowledge and Practice Regarding Radiation Control & Safety: A Cross Sectional Study on Radiological Technologists Working with Radio-diagnostic Centers in Dhaka City
Radiology and imaging is an integrated part of global medical science. Most of the diseases are now diagnosed by using radiology and imaging technology. Ionizing radiation is used by Radiology and Imaging Technologists d...
Different disposal mechanisms and Isocyanate Waste - A Short Communication
The present communication deals with different waste disposal mechanisms and their feasibility with Isocyanate wastes produced in the Production Plant. Isocyanate wastes pose a substantial present or potential hazard to...
Low Dose 5-Azacytidine Treatment Induce in KYSE450 Esophageal Carcinoma Cell Line
The objective is to discuss the treatment effects of low doses of 5 – Azacytidine to KYSE450 esophageal cancer cell line. The cells of KYSE450 esophageal cancer cell line were used different drug concentrations of 5-Aza...
IS6110 gene in Mycobacterium tuberculosis complex in Tuberculosis meningitis-Clinical Applications for Disease Monitoring
Tuberculosis meningitis (TBM) is the most common form of chronic infection of central nervous system. Regardless of the extent of the problem, the general diagnostic outlook is discouraging specifically; there is no gene...