PD-1/PD-L1 Blockade: A New Promising Therapy for the Treatment of Pancreatic Cancer?
Journal Title: Pancreas – Open Journal - Year 2018, Vol 2, Issue 1
Abstract
Programmed cell death protein 1 (PD-1), a member of the CD28 family, is an immune-checkpoint receptor expressed on a variety of immune cells, such as T-cells, monocytes, B-cells, dendritic cells, and tumor-infiltrating lymphocytes (TILs).1 PD-1 major role is to limit the activity of T-cells in peripheral tissues at the time of an inflammatory response to constrain autoimmunity and tissue damage.1,2 Engagement of PD-1 by one of its two known ligands (PD-L1 and PD-L2) inhibits kinases involved in immune cell activation.2 Interestingly, PD-1 has an opposite function in Treg lymphocytes.3
Authors and Affiliations
Nicoletta Gagliano
Keywords
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- EP ID EP556740
- DOI 10.17140/POJ-2-e007
- Views 184
- Downloads 0
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