Pediatric and Adolescent Malignant Ovarian Tumors: Mansoura 5 - Year Experience
Journal Title: Journal of Cancer and Tumor International - Year 2017, Vol 6, Issue 2
Abstract
Background: Pediatric ovarian tumors are rare. The aim of this work is to study the epidemiological characteristics and treatment outcome of these tumors in our locality. Methods: This retrospective study was performed in accordance with the ethical policies. Between January 2011 to December 2015, Thirteen cases of pediatric ovarian cancers were recorded in the Pediatric Oncology Unit of Oncology Center of Mansoura University and the Clinical Oncology & Nuclear Medicine Department of Mansoura University Hospital. The clinico-epidemiologic data and the treatment protocols were analyzed. Results: The median age was 10 years (range: 2-17). Presenting symptoms were mainly lower abdominal pain (6; 46.2%) and palpable abdominal mass (4; 30.7). Through laparotomy all patients underwent unilateral salpingo-oophorectomy except one case for whom bilateral salpingio-oophorectomy was done. Six patients were stage I (46.2%), 2 patients were stage II (15.4%) and 5 patients were stage III tumors (38.4%). The majority had germ cell tumors (11; 85%). Adjuvant chemotherapy was given to all cases. Further chemotherapy was needed in 6 cases due to progression or recurrence. The median follow up was 35 months while the median overall survival was 40 months. Mortality rates were 90% in stages II and III together. The advanced stages and yolk sac pathology had the highest mortality. One of the survived cases got married and delivered a baby. Conclusion: Germ cell tumors are the commonest pediatric malignant ovarian tumors. Multimodality treatment is essential. Fertility preservation should be respected. Our mortality rates are relatively high.
Authors and Affiliations
Mohamed Sarhan, Amal Halim, Ibrahim Elzayat, Tamer Saber, Amira El-Hawary, Adel El-Badrawy, Hanan Wahba, Hend El-Hadaad, Omar Farouk, Wagdi El Kashif
Keywords
Related Articles
- EP ID EP309006
- DOI 10.9734/JCTI/2017/36261
- Views 123
- Downloads 0
MiRNA and Target Oncogene Regulation in Triple Negative Breast Cancer: An Age, Ethnic and Environmental Related Neoplastic Event
Triple-negative breast cancer is a type of aggressive breast cancer without the immunohistochemical expression of estrogen receptors, progesterone receptors and human epidermal growth factor receptor-2; with poor prognos...
Epidemiology, Diagnosis and Treatment Outcomes of Skin Melanoma in the Republic of Belarus
The primary incidence of skin melanoma in the Republic of Belarus over 25 years (from 1991 through 2015) has increased 3.3-fold (from 2.6 to 9.0 per 100,000 population). A higher level of urban population incidence, a la...
Neuroblastoma: Current Imaging and Therapeutics
Neuroblastoma is the most common solid abdominal tumor in children under the age of 2 years and accounts for approximately 15% of childhood mortality due to cancer. Its clinical behavior can vary from spontaneous regress...
Neoadjuvant Chemoradiotherapy and Chemotherapy in Patients with Locally Advanced Rectal Cancer
Aims: Evaluate the role of neoadjuvant chemoradiotherapy (CRT) followed by an additional cycle of chemotherapy and total mesorectal excision (TME) in patients with locally advanced rectal cancer on the rate of pathologi...
Association between Age, Tumour Location and Survival of Patients in Morocco
Aims: Cancer is a major burden of disease worldwide. Each year, tens of millions of people are diagnosed with cancer around the world, and more than half of the patients eventually die from it. The present work aims to b...