PELLETIZATION TECHNIQUES: A LITERATURE REVIEW
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
In present times, the pelletization technologies are gaining much attention as they represent an efficient pathway for manufacture of oral drug delivery systems. This is due to the reason that pellets offer many therapeutic, technological as well as biopharmaceutical advantages over the conventional oral dosage forms. Pelletization technique enables the formation of spherical beads or pellets with a mean diameter usually ranging from 0.5-2.0 mm which can be eventually coated for preparation of modified release dosage forms. Pelletization leads to an improvement in flowability, appearance and mixing properties thus avoiding generation of excessive dust and reducing segregation, and, generally, eliminating undesirable properties and improving the physical and chemical properties of fine powders. Pellets are produced by various techniques, such as, extrusion/ spheronization, layering, cryopelletization, freeze pelletization, spray congealing, spray drying and compression. Amongst various techniques, Extrusion/Spheronization technique is the most widely utilized technique due to its high efficiency and simple and fast processing. The aim of this paper is to review some general aspects about pellets and pelletization and some common techniques being utilized in the pharmaceutical industry.
Authors and Affiliations
Supriya Punia , Rajni Bala , A. C. Rana
Keywords
Related Articles
- EP ID EP129986
- DOI -
- Views 94
- Downloads 0
PHYTOSOME LOADED NOVEL HERBAL DRUG DELIVERY SYSTEM: A REVIEW
Novel drug delivery system (NDDS) is an innovative approach to drug delivery that addresses the limitations of the traditional drug delivery systems. If the novel drug delivery system is applied in herbal drugs, it shoul...
DEVELOPMENT AND CHARACTERIZATION OF PREDNISOLONE LIPOSOMAL GEL FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
The present objective for the study was to prepare prednisolone liposomal gel intended for topical application. Various liposome formulations were prepared using Vortexing Sonication technique using vacuum rotator evapor...
ETHNOMEDICINAL KNOWLEDGE AMONG THE ADI TRIBES OF LOWER DIBANG VALLEY DISTRICT OF ARUNACHAL PRADESH, INDIA
The paper presents the traditional ethnomedicinal knowledge and uses of various plants among the Adi tribes of Lower Dibang Valley district of Arunachal Pradesh (India). These people in rural villages are still more or l...
PENETRATION ENHANCEMENT OF MEDICINAL AGENTS
Many current therapeutic agents like antibiotics, ionizable and peptide drugs are impermeable or do not possess the requisite physicochemical properties for efficient transport through outer tissue barrier to attain ther...
CURRENT TECHNIQUES IN PULSATILE DRUG DELIVERY: A REVIEW
The purpose of writing this review on pulsatile drug delivery system (PDDS) is to compile the recent literatures with special focus on the different types and approaches involved in the development of the formulation and...