PEMPHIGUS VULGARIS: AN INSIGHT ON CONVENTIONAL AND EMERGING TREATMENT MODALITIES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 3
Abstract
According to Sir William Osler, Mouth is the mirror of the body which reflects systemic diseases. The oral mucosa may be affected by a variety of muco-cutaneous diseases and oral lesions may occur first or very early in several muco-cutaneous disorders. Pemphigus is a group of potentially life threatening, chronic auto immune disorder characterized by epithelial blistering affecting muco-cutaneous surfaces. Autoantibodies in pemphigus vulgaris are directed against desmoglein in epithelial desmosomes, and the immune deposits result in intra-epithelial splitting (acantholysis). Oral lesions in the form of blisters and erosions are the first to manifest, and diagnosis is made by positive nikolsky’s sign, coupled with characterstic histopathology and immunofluorescent features. Corticosteroids form the mainline of treatment, but adjuvant and newer therapies are also been used at an increasing rates. This article deals about the etio-pathogenesis, clinical characterstics, diagnosis and treatment strategies for pemphigus vulgaris.
Authors and Affiliations
Shamimul Hasan, Nabeel Khan, Osama Sherwani, Vasundhara Bhatt, Himangi Srivastava
Keywords
Related Articles
- EP ID EP161718
- DOI 10.7897/2230-8407.04303
- Views 96
- Downloads 0
PREVALENCE AND RISK FACTORS OF ARTHRITIS: A STUDY AMONG TYPE II DIABETIC PATIENTS; BANGLADESH PERSPECTIVE
The prevalence of arthritis in type II diabetic patients and its causative risk factors from this region is rarely found, where type II diabetes is in epidemic form. Total 410 patients were agreed to take part in this su...
SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF TOLPERISONE HYDROCHLORIDE AND DICLOFENAC SODIUM IN SYNTHETIC MIXTURE
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of Diclofenac sodium and Tolperisone hydrochloride in bulk and synt...
OVERVIEW OF INDIAN MEDICINAL TREE: BAMBUSA BAMBOS (DRUCE)
India has a great wealth of various naturally occurring plant drugs which have a great potential for pharmacological activities. Bambusa bambos family Graminae is highly reputed Ayurvedic medicinal tree commonly known as...
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF OFLOXACIN BY DIRECT COMPRESSION METHOD
Ofloxacin is a broad-spectrum, synthetic fluoroquinolones antibacterial agent for oral administration. The bioavailability of ofloxacin in the tablet formulation is approximately 98 %. It is extremely bitter in taste, wa...
ENUMERATION OF MICROORGANISMS ASSOCIATED WITH THE DIFFERENT STAGES OF BREAD PRODUCTION IN FUTMIN BAKERY, NIGERIA
Microbiological analysis of different stages of bread which includes dry mixture, non-dry mixture, mixture of ingredient with flour, dough formation, milling, cutting, proofing, baking and cooling stage were obtained fro...