Pentraxin 3 as A Cardiovascular Marker in Primary Hyperparathyroidism
Journal Title: Journal of Endocrinology and Diabetes - Year 2018, Vol 5, Issue 4
Abstract
Aim: Pentraxin 3 (PTX3) is an acute-phase glycoprotein, which is increased in patients with cardiovascular disease (CVD) and considered as a predictor of CVD in the general population. Accumulating evidence suggests that even mild primary hyperparathyroidism (PHPT) has an elevated risk for CVD. We aimed to investigate plasma PTX3 levels before and after parathyroidectomy in patients with primary hyperparathyroidism and determine its relationship with cardiovascular risk factors Material and Method: Twenty-nine patients with PHPT and 26 healthy controls were enrolled in the study. Anthropometric and laboratory parameters were recorded both before and 6 months after parathyroidectomy. Serum PTX3 levels were measured using a human PTX3 enzyme-linked immunosorbent assay. Results: Plasma PTX3 concentrations were similar between before and after parathyroidectomy and control group (10.97 ± 16.0, 11.97 ± 11.49, 7.88 ± 9.48, respectively, p>0.05). Systolic blood pressure, diastolic blood pressure, carotid intima-media thickness (CIMT) and calcium, parathormone, fasting plasma glucose, alkaline phosphatase concentrations were higher in the PHPT group (p< 0.05). Creatinine and phosphorus concentrations were higher in the control group (p< 0.05). PTX3 was not correlated with cardi-metabolic risk factors except body mass index (BMI) (r2:0.414, p:0.0253). Conclusion: Plasma PTX3 was not increased as well was not changed after parathyroidectomy in patients with PHPT. The PTX3 was correlated with BMI; however, it was not associated with other cardio-metabolic risk factors including DBP, CIMT, and CRP. These findings might support PTX3 cannot be used as a cardio-metabolic risk marker in patients with PHPT.
Authors and Affiliations
Muhammed Kizilgul, Mustafa Calışkan, Ozgur Ozcelik, Selvihan Beysel
Keywords
Related Articles
- EP ID EP413535
- DOI 10.15226/2374-6890/5/4/001113
- Views 108
- Downloads 0
HSP27 and Atherogenic Index of the Plasma - heralding cardiovascular complications inIndian diabetic subjects
Aim: To evaluate the importance of Heat shock protein 27 (HSP27) and Atherogenic Index of the Plasma (AIP) in diabetic subjects, as indicators of cardiovascular disease progression in diabetic subjects. Materials and Me...
Psychosocial Aspects of Diabetic Patients: A Pilot Study In Saudi Arabia
Introduction: In Saudi Arabia, diabetes affects one in four individuals. It greatly impacts on their Quality of Life and is a heavy burden on the country. Many patients are not compliant with their treatments which leads...
Neonatal Severe Hyperparathyroidism: A Fatal Case
Background: Neonatal severe primary hyperparathyroidism (NSHPT) is a rare disorder that is usually caused by homozygous inactivating mutations in the CASR gene encoding the calcium sensing receptor (CaSR). Although parat...
Non-classical Congenital Adrenal Hyperplasia: the challenge of an accurate diagnosis
We present the case of a 24 year-old lady with mild congenital adrenal hyperplasia (CAH) who presented with infertility, hirsutism and clitoromeglay and increased 17 alpha hydroxy progesterone serum levels. She was treat...
3-Iodothyronamine: A High Potency Metabolic Hormone and its Potential for Therapeutic Applications
3-Iodothyronamide (T1AM) is a naturally produced endogenous hormone like molecule. Only recently it has been discovered in the past decade, the proceeding body of research emerging from its initial discovery has revealed...