Peripheral Nerve Function Changes Due to Hypoxia in Obstructive Sleep Apnea
Journal Title: Türk Uyku Tıbbı Dergisi - Year 2019, Vol 6, Issue 2
Abstract
Introduction: Chronic hypoxia is known to be one of the risk factors for peripheral neuropathy. However, the effect of intermittent hypoxia on peripheral nerves is not fully understood. This study evaluated the relation between intermittent hypoxia and peripheral nerve function in Obstructive Sleep Apnea (OSA) patients. Materials and Methods: In this retrospective study, 86 patients who underwent polysomnography (PSG) and electroneuromyography were enrolled. Participants with diseases affecting peripheral nerves and lung function were excluded from the study. Hypoxia parameters were obtained from the PSG study. Lower extremity motor and sensory nerve conduction studies of all patients were evaluated. Results: In patients with OSA, peroneal nerve distal motor latency and sural sensory nerve action potential amplitude was low and velocity was significantly slower than controls (p<0.001, p<0.04, p<0.001, respectively). After adjustment for age and body mass index, the results remained significantly (p<0.001, p<0.01, p<0.001, respectively). The nerve conduction results were significantly correlated with the hypoxia parameters. After adjustment for confounding factors, logistic regression analyses revealed that hypoxia parameters were independently associated with nerve conduction results. Conclusion: OSA and intermittent hypoxia may affect both motor and sensory nerve conduction, which suggests that subclinical sensorimotor peripheral neuropathy is associated with OSA. The related intermittent hypoxia and OSA may be a cause of axonal and demyelinating neuropathies.
Authors and Affiliations
Aynur Yılmaz Avcı, Suat Avcı
Keywords
Related Articles
- EP ID EP582171
- DOI 10.4274/jtsm.galenos.2019.27147
- Views 136
- Downloads 0
Comorbidity of Obstructive Sleep Apnea Syndrome, Cronic Obstructive Lung Disease and Asthma Chronic Airway Diseases and Sleep Apnea
Objective: Sleep disorders are conditions that often interfere with chronic airway diseases and affecting both the course of illness and the quality of life. Obstructive sleep apnea syndrome (OSAS) is the most common gro...
Restless Legs Syndrome and Cognitive Functions
Objective: Restless Legs syndrome (RLS) is a common sleep disorder in clinical practice. In the prevalence studies conducted in different populations for RLS, different results ranging from 5% to 15% were obtained. This...
The Relationship Between the Physical Activity Level and Fatigue Perception, Quality of Life and Psychological Status in Patients with Obstructive Sleep Apnea Syndrome
Objective: Currently, there is a need for research that examines factors which affect physical activity (PA) participation in Obstructive Sleep Apnea syndrome (OSAS) patients. The purpose of this study was to investigate...
Sleep Apnea in Organic Solvent Exposed Workers
Objective: To evaluate the frequency of sleep apnea in solvent exposed workers and to find out the relationship between exposure level and sleep apnea. Materials and Methods: The study group included street sign painters...
Evaluation of Sleep and Television Viewing Habits of Primary School Students
Objective: Sleep is crucial for healthy growth and development of children. Unsuitable television viewing habits are one of the important factors that disturb sleep patterns. This study was conducted to evaluate the slee...