Perspectives of The Pharmacological Modulation of Ca2+/ Camp Signaling Interaction as a New Neuroprotector Therapeutic Strategy for Amyotrophic Lateral Sclerosis (ALS)
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2017, Vol 1, Issue 1
Abstract
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease characterised by progressive muscular paralysis reflecting selective degeneration and death of motor neurons in the primary motor cortex, brainstem and spinal cord. Several evidences suggest the involvement of the imbalance of the intracellular Ca2+ homeostasis in the death of motor neurons in ALS. It is now recognized that the interaction between intracellular signaling pathways mediated by Ca2+ and cAMP (Ca2+/cAMP signalling interaction) plays as a key role in several cellular processes of mammalians, including neurotransmission and neuroprotection. Our previous studies have indicated that the pharmacological modulation of the Ca2+/cAMP signalling interaction by the combined use of the Ca2+ channel blockers (CCBs) and drugs that increment of the intracellular concentration of cAMP (cAMP-enhancer compounds) can increase neurotransmission, and stimulate neuroprotective response in neurodegenerative diseases. We have proposed that the pharmacological modulation of Ca2+/cAMP signalling interaction could open a new avenue for the drug development more effective and safer for treating neurodegenerative diseases, including ALS. In this review article, we discuss the perspectives of the pharmacological modulation of the Ca2+/ cAMP signalling interaction as a new therapeutic strategy for ALS.
Authors and Affiliations
Afonso Caricati-Neto, Leandro Bueno Bergantin
Keywords
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- EP ID EP567234
- DOI 10.26717/BJSTR.2017.01.000131
- Views 186
- Downloads 0
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