Pharmaceutical Analysis of Eptifibatide via Simple, Rapid, Economical UV-Spectrophotometric Methods
Journal Title: JOURNAL OF PHARMACEUTICAL TECHNOLOGY, RESEARCH AND MANAGEMENT - Year 2015, Vol 3, Issue 1
Abstract
Eptifibatide is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class. Pharmaceutically it is applied to reduce the risk of acute cardiac ischemic events. The present work reveals two simple, rapid and economical UuV-Spectrophotometric methods for pharmaceutical analysis of Eeptifibatide bulk and in parenteral formulation. The ‘Method I’ is based on the Zero Order Spectrophotometric determination of drug at its wavelength maximum 218.20 nm and ‘Method II’ employed First Order Derivative - Aarea Uunder Curve (AUauC) technique in which the area has been integrated between two wavelengths 220.20 to 237.20 nm. The drug obeyed linearity in the concentration range of 3 - 18 μg/mLl with coefficient of correlation; greater than 0.999 in both methods. The amounts of drug determined by both methods are in conformity with label claim. These methods are validated for accuracy, precision and ruggedness with % RSD value less than 2.0.
Authors and Affiliations
Sushant S. Patil , Saurabh B. Ganorkar , Ataul A. Shirkhedkar
Keywords
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- EP ID EP596696
- DOI 10.15415/jptrm.2015.31004
- Views 138
- Downloads 0
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