Pharmaceutical and Analytical Studies on Guduchi Kwatha Prepared by Varying Proportions of Water
Journal Title: Journal of Ayurvedic and Herbal Medicine - Year 2016, Vol 2, Issue 4
Abstract
Background: Kwatha preparation is one among the Pnachvidha Kashaya Kalpana. The ratio of water and hardness of drug plays an important role during preparation of Kwatha. Disparities in proportions of liquid (water) to be mentioned can be observed in the classics, which are based on the quality (the hardness) and quantity of the raw material being used in the pharmaceutical procedure. Aims and objective: The objective of the present study was to evaluate the significance of proportion of water in the preparation of Kashaya and Ghana. The water proportion was fixed as 4 parts, 8 parts and 16 parts. Material and methods: Three batches of Kashaya and Ghana with each proportion were prepared considering the batch size as 1 kg and findings were systematically recorded. Organoleptic evaluation, Physico-chemical parameters of Kwatha and Ghana, HPTLC and HPLC were carried out. Result and discussion: Average time took for 1/4th reduction was found to be 339 min, 570 min and 960 min and in the preparation of Kashaya with 4 parts, 8 parts and 16 parts of water respectively while Average temperature maintained during the process was 95-1000 C. An average of 6.23%, 6.24% and 6.32% Ghana was obtained from the Kashaya in 4,8,16 parts of water respectively. The change in organoleptic parameters, physico - chemical parameters, HPTLC & HPLC study was observed. The physico-chemical parameters of all the samples presented negligible differences. After spray, 7 spots were observed in the sample prepared with 4 parts of water and remaining samples provided only 5 spots. In HPLC study, the batch 4, 8 and 16 have almost similar concentrations. Conclusion: Though the percentage of Ghana is similar in all the batches; during the pharmaceutical procedure, it is advisable to add 8 parts of water. This facilitates proper soaking and boiling of the raw material.
Authors and Affiliations
Ashish Verma*, Hetal Janani, Shobhnath Yadav, Galib Galib, P. K. Prajapati
Keywords
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