PHARMACEUTICAL ASSESSMENT OF GYNAECOLOGICAL POWDERS WITH SODIUM ALGINATE CONTAINING A LACTIC ACID-CHITOSAN COMPLEX
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2018, Vol 0, Issue
Abstract
The insufficient duration of the drug’s contact with the vaginal mucosa does not provide adequate pH, conditioning the physiological biocenosis of the organ. This effect is hampered by numerous anatomic and physiological conditions which do not facilitate prolonged contact of the drug with the application site. This study has shown the impact of the used excipients and the ratio of lactic acid to chitosan on pH, dynamic viscosity and adhesiveness of methylcellulose gels obtained from powders. The addition of sodium alginate and excipients to these complexes allows various formulations to be obtained over a wide range of pH. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and sodium alginate in comparison to gels without sodium alginate. Studies of the work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentrations on the value of the work of adhesion.
Authors and Affiliations
Katarzyna Małolepsza-Jarmołowska
CELL BINDING AND PENETRATION OF QUATERNIZED CHITOSAN DERIVATIVES
Chitosan (Ch) is an attractive biopolymer with multiple reactive groups. However it is poorly soluble at neutral pH. Quaternization improves its solubility and permits the development of various positively charged drug d...
SYNTHESIS OF NANOCOMPOSITE CHITOSAN-TiO2 AND ITS APPLICATION AS PHOTODEGRADATION AGENT OF METHILEN BLUE IN AQUEOUS MEDIUM
Synthesis of nanocomposite chitosan-TiO2 have been done. Nanocomposite made of chitosan was isolated from crab shell namely α-chitosan and squid pens as β-chitosan. Nanocomposite was synthesized by combining the function...
NEW AFFINITY SORBENTS FOR PURIFICATION OF RECOMBINANT PROTEINS WITH THE USE OF CHITIN-BINDING DOMAIN AS AN AFFINITY TAG
With the increasing amounts of recombinant proteins production the problem of effective purification of produced proteins became one of major topics for research nowadays. Affinity chromatography proved to be the most do...
MODIFIED DIBUTYRYLCHITIN FILMS AS MATRICES FOR CONTROLLED IBUPROFEN RELEASE
In view of ongoing interest in biodegradable polymers, dibutyrylchitin was used as a matrix for controlled release of a model substance. Transdermal systems (films) are presently more commonly used as an alternative to s...
VISCOMETRIC STUDIES OF MICROCRYSTALLINE CHITOSAN/POLY(VINYL ALCOHOL) MIXTURES
In the present paper, the results of viscosity measurements in dilute solutions of microcrystalline chitosan (MCCh) with poly(vinyl alcohol) (PVA) of different degrees of hydrolysis are presented. Microcrystalline chitos...