PHARMACEUTICAL TECHNIQUES FOR THE FABRICATION OF POOR WATER SOLUBLE DRUGS – A REVIEW
Journal Title: Baqai Journal of Health Sciences - Year 2018, Vol 21, Issue 1
Abstract
Pharmaceutical technologies for increasing the solubility of drug substances have a prime role in its faster dissolution and maximum absorption in the systemic circulation. Majority of the drugs possesses low solubility leading to poor absorption and erratic bioavailability and thus failed to achieve a desired pharmacological response. Therefore formulation scientists have adopted various techniques to overcome solubility and bioavailability issues following oral administration. The selection of technique is primarily based on the physicochemical characteristics of drug and dosage form. The present review highlights the importance of solubility with a brief description of conventional and novel approaches that could be used for solubility enhancement.
Authors and Affiliations
Rabia Noor, Syed Muhammad Farid Hasan, Farah Khalid
Keywords
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