Pharmaco-technological researches for development of sachet composition
Journal Title: Фармацевтичний журнал - Year 2017, Vol 5, Issue 5
Abstract
In the article it is presented data on the relevance of drugs from the group of analgesics-antipyretics in the form of fast dissolving solid dosage forms and excipients for its manufacture are described. The advantages of a sachet as a solid dosage form are described. For developing a sachet with anti-inflammatory properties, the features of active pharmaceutical ingredients interrelation and their physicochemical properties, which determine the technology, are shown. The purpose of this work was to select the excipients for improvement the pharmaco-technological and organoleptic characteristics of the sachet. We studied 27 excipients 5 functional groups. The experiment is based on the Latin cube of the second order. Technology was the mixing of components. The obtained mass was tested twice on pharmaco-technological parameters and the characteristics of the solution. Experimental data were subjected to statistical analysis by the method of dispersion analysis. The results were expressed using ranked rows of benefits and bar charts. The results of the study present the effect of excipients from groups of alkaline and acid fractions, dyes, flavors, fillers on the quality of the sachets. The results of the study show that the different tested excipients show the greatest influence on appearance of the mass, bulk density, density after shrinkage, Carr`s index, fluidity, angle of the slope, mass loss in drying, solution appearance, solution smell, solution taste and pH of the solution. Generalized results of dispersion analysis showed that calcium phosphate, citric anhydrous acid, maleic acid, curcumin, lemon-lime flavor and sugar powder improve the pharmacological-technological and organoleptic characteristics of the studied sachet. In the result of the work, the selection of excipients in the development of a sachet is scientifically substantiated. The influence of the exipiences nature on the pharmaco-technological indicators sachets and organoleptic properties was studied. It was selected the excipients for the optimal sachet composition with anti-inflammatory properties.
Authors and Affiliations
O. V. Tryhubchak, S. N. Gureyeva, O. A. Yuryeva, А. М. Goy
Keywords
Related Articles
- EP ID EP556073
- DOI 10.32352/0367-3057.5-6.17.04
- Views 53
- Downloads 0
Determination of the qualitative and quantitative content of hydroxycinnamic acids in Gentiana Cruciata L. herb
Gentiana cruciata L. is a herbaceous perennial flowering plant in the Gentianaceae family. This plant is widespread in the territory of Ukraine, namely the southern forest areas, forest-steppe and Crimea. Gentiana crucia...
Integrated use of the bark of spindle tree (Euonymus europaea L.). investigation of lipophilic substances
The bark and fruit of European spindle tree (Euonymus europaea L.) has long been used in folk medicine as an anthelmintic, anti-insecticide, as well as for treatment ringworm and eczema. However, what substances responsi...
Experimental study of antimicrobial activity of gel based on PHDP and its combinations with azelaic acid and benzoyl peroxide
The creation of combined medicines for the treatment of dermatological diseases based on the substances of natural origin, in particular phenol-hydrophobic drug propolis with reduced content of benzoyl peroxide and azela...
Evaluation of factions antigens disintegration fungal cells Candida albicans and Candida tropicalis if advised candidiasis
Candidiasis – one of the most common fungal diseases humanity has ever faced. Etiological factors of the disease are most often Candida albicans and Candida tropicalis. To fight Candida infection has been actively conduc...
Study of influence of the surface-active substances concentration on releasing of praziquantel from the rectal suppository
Acne dermatosis (rosacea, perioral dermatitis, seborrheic dermatitis etc.) are one of the most actual problem in dermatology. Praziquantel is an antiparasitic medication effective towards trematodes, cestodes. Investigat...