Pharmacodynamic Modeling of Sequence-Dependent Antitumor Activity of Insulin-like Growth Factor Blockade and Gemcitabine
Journal Title: The AAPS Journal - Year 2012, Vol 14, Issue 1
Abstract
The online version of this article (doi:10.1208/s12248-011-9308-3) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Amit Khatri, Richard C. Brundage, Jessica M. Hull, Brent W. Williams, Douglas Yee, Mark N. Kirstein
Small-molecule agonists and antagonists of the opioid receptor-like receptor (ORL1, NOP): Ligand-based analysis of structural factors influencing intrinsic activity at NOP
The recently discovered fourth member of the opioid receptor family, the nociceptin receptor (NOP) and its endogenous ligand, the heptadecaptide nociceptin, are involved in several central nervous system pathways, such a...
Exploring the demand for a voluntary medicare prescription drug benefit
The purposes of this study were (1) to assess the utility of the economic theory of demand for insurance for modeling voluntary Medicare drug benefit enrollment decisions and (2) to explore the degree of adverse selectio...
Nonviral gene delivery: What we know and what is next
Gene delivery using nonviral approaches has been extensively studied as a basic tool for intracellular gene transfer and gene therapy. In the past, the primary focus has been on application of physical, chemical, and bio...
Role of Physiological Intestinal Water in Oral Absorption
Water volume has impact when the compound has low aqueous solubility. For example, the absorption of compounds with a Biopharmaceutics Classification System class 2 or 4 is likely to be solubility-limited. Provided the f...
Simplification of Complex Physiologically Based Pharmacokinetic Models of Monoclonal Antibodies
The online version of this article (doi:10.1208/s12248-014-9591-x) contains supplementary material, which is available to authorized users.