Pharmacodynamic Modeling of Sequence-Dependent Antitumor Activity of Insulin-like Growth Factor Blockade and Gemcitabine
Journal Title: The AAPS Journal - Year 2012, Vol 14, Issue 1
Abstract
The online version of this article (doi:10.1208/s12248-011-9308-3) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Amit Khatri, Richard C. Brundage, Jessica M. Hull, Brent W. Williams, Douglas Yee, Mark N. Kirstein
Keywords
Related Articles
- EP ID EP681183
- DOI 10.1208/s12248-011-9308-3
- Views 88
- Downloads 0
Paradigm Shift in Toxicity Testing and Modeling
The limitations of traditional toxicity testing characterized by high-cost animal models with low-throughput readouts, inconsistent responses, ethical issues, and extrapolability to humans call for alternative strategies...
Survey of International Regulatory Bioequivalence Recommendations for Approval of Generic Topical Dermatological Drug Products
The objective of this article is to discuss the similarities and differences in accepted bioequivalence (BE) approaches for generic topical dermatological drug products between international regulatory authorities and or...
Influence of fluoxetine on olanzapine pharmacokinetics
Conventional antidepressant treatment fails for up to 30% of patients with major depression. When there are concomitant psychotic symptoms, response rates are even worse. Thus, subsequent treatment often includes combina...
A Platform for Characterizing Therapeutic Monoclonal Antibody Breakdown Products by 2D Chromatography and Top-Down Mass Spectrometry
The online version of this article (doi:10.1208/s12248-012-9361-6) contains supplementary material, which is available to authorized users.
Characterization of Nanoporous Surfaces as Templates for Drug Delivery Devices
Bare silicon wafers, gold-coated silicon wafers, and nanoporous gold-coated silicon wafers were obtained from Nanomedsystems, Charlottesville, VA, USA (formerly Setagon, Inc.). A bare metal stent (Palmaz-Schatz®...