Pharmacogenetic Tests in the Nephrological Clinic
Journal Title: Нирки - Year 2016, Vol 4, Issue 18
Abstract
Selection of antihypertensive agents using pharmacogenetic tests and individual tolerance is essential in practical nephrology. Antihypertensive first-line drugs are metabolized through various CYP isoforms (CYP2D6, CYP2C9, CYP2C19 and CYP3A4/5). These isoforms are the most significant for the patient in response to the drug. From a clinical point of view, it is important to establish the slow metabolizers, because in them we should use other doses of antihypertensive drugs that differ from the standard ones.
Authors and Affiliations
D. D. Ivanov, O. O. Melnik
Keywords
Related Articles
- EP ID EP207111
- DOI 10.22141/2307-1257.4.18.2016.84320
- Views 104
- Downloads 0
Application of genetic testing in steroid-resistant nephrotic syndrome
Nephrotic syndrome, one of the most frequent kidney conditions affecting patients of all ages, has significant genetic composition, especially in individuals who do not respond to glucocorticoid treatment. The recent dev...
The current strategy was the use of neuroprotective protein diet purposes.
This article provides an overview of the scientific evidences on the use of low-protein diet by patients with chronic kidney disease. Their analysis show that low-protein diet refers to the recommendations of a high lave...
Symposium «Thrombotic Thrombocytopenic Microangiopathy»
.
Hepatitis C virus Infection in Nephrology Patients
Hepatitis C virus (HCV) infection leads to chronic liver disease, but also to extra-hepatic manifestations [1]. These include mixed cryoglobulinemia, lymphoproliferative disorders, and renal disease. HCV infection has be...
Influence of phytotherapy on metabolic status and urine microbiota in patients with urolithiasis — calcium oxalate nephrolithiasis after shock wave lithotripsy
Background. The study of the problem of urolithiasis in recent years has reached a qualitatively new level in connection with the use of a multidisciplinary approach and the principles of evidence-based medicine. In the...