PHARMACOGENOMIC ANALYSIS OF SNPs OF ACE GENE IN STROKE
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
The commonly occurring neurological disorder is stroke disease, which is a third largest killer in the world. Study of genes involved to cause stroke isone of the way to find drugs for prevention or treatment of stroke. The purpose of the present study is to develop therapeutics by giving individualizedmedicine based on significant single-nucleotide polymorphisms (SNPs) involved in the pathogenesis of disease. Genome-wide association approachscans the entire genome looking through thousands of genetic variants SNPs with an aim to discover novel gene associated with a specific disease.In the present study, the most intensively investigated candidate gene is angiotensin-I converting enzyme (ACE). The normal and mutated forms ofACE gene are selected, and the active site of predicted protein structure is identified where the selected ligand binds. The selected ligands of bothexisting and modified molecules were docked with predicted protein using AutoDock tool. The docking results were analyzed based on the maximumnumber of hydrogen bond interactions. The results predicted that anti-hypertensives, anticoagulants, tissue plasminogen activators (TPAs) havestrong interaction with stroke genes. The docking studies showed that ACE gene strongly interacts with r-TPA and is used for treatment of strokes.Keywords: Stroke, Single-nucleotide polymorphism, Angiotensin-I converting enzyme, Individualized medicine.
Authors and Affiliations
Maheswari L Patil, Seema J Patel
Keywords
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