Abstract

Objective: To study pharmacognostic evaluation and anti - inflammatory activity of Phyllanthus reticulatus Poir. (P.reticulatus) fruit. Methods: The fruit sample was studied by macroscopical, microscopical and other WHO recommended methods for standardisation. The hydroalcoholic extract of ripe fruit was also screened for anti-inflammatory activity by carrageenan induced left hind paw oedema in rat at doses of 200 mg/kg and 400 mg/kg, orally. Results: Transverse section of fruit and powder study showed the presence of epicarp, mesocarp, endocarp, fibres and sclereids. Hydroalcoholic extract of fruit showed significant (P<0.01 ) reduction of paw volume when compared with diclofenac sodium. The extract showed anti - inflammatory activity at 200 mg/kg and 400 mg/kg and was comparable with diclofenac sodium. Conclusions: Pharmacognostic profile of Phyllanthus reticulatus provides the simplest and quickest means to establish the identity and purity and thereby assure the quality of sample. The hydroalcoholic extract shows significant anti - inflammatory activity at both doses when compared with standard drug diclofenac sodium (100 mg/kg).

Authors and Affiliations