PHARMACOGNOSTICAL EVALUATION AND ANTICONVULSANT ACTIVITY OF STEM OF ABUTILON INDICUM LINN SWEET
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 8
Abstract
Objective: To investigate the pharmacognostical characteristics and in vivo anticonvulsant activity of chloroform, ethanol (90%) and aqueous extracts of Abutilon indicum Linn sweet stem.Methods: The Abutilon indicum Linn sweet stem were successively extracted using chloroform, ethanol and aqueous solvent (water). The extracts were screened for phytochemicals using HPTLC and GC-MS techniques. The extracts were also screened for acute toxicity and anticonvulsant activity, against MES and PTZ induced convulsions, using Wistar albino rats.Results: The phytochemical screening study reveals the presence of more chemical constituents in chloroform extract followed by ethanol and aqueous extract. We found no significant changes in average body weight of animals, up to tested oral dose of 3000 mg/kg, during acute toxicity study. The in vivo study reveals the anticonvulsant activity of chloroform and ethanol extract against MES and PTZ induced convulsions. The chloroform extract is found to be more potent, similar to Phenytoin, in controlling both MES and PTZ induced convulsions than ethanol and aqueous extracts.Conclusion: The results obtained suggest that the chloroform extract of Abutilon indicum stem has remarkable anticonvulsant activity. Also, our study indicates the potential application of Abutilon indicum stems in the treatment of convulsive disorders as a need of modern health science. However, the further studies are needed to screen the active constituent having an anticonvulsant effect.Â
Authors and Affiliations
Mahanthesh M. C. , Jalalpure S. S.
Keywords
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