Pharmacokinetics of a Once Daily Dosing Regimen of Gentamicin in a Patient with Delayed Wound Healing
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 71, Issue 6
Abstract
<span>Background: </span><span>Gentamicin is used for the treatment of serious gram-negative infections and has low therapeutic index. This may lead to several side effects, though therapeutic drug monitoring (TDM) is important in gentamicin therapy.<br /> </span><span>Aim</span><span>: To report the pharmacokinetics of gentamicin using a once-daily dosing regimen.<br /> </span><span>Clinical presentation and intervention: </span><span>The patient was a 78-year-old male. His weight was 78 kg and he was 1.75 m in height. He was admitted to the hospital complaining of an infected wound secondary to chronic limb ischaemia. Once-daily dosing of gentamicin (360 mg by infusion over 30 minutes) was prescribed to this patient, in combination with flucloxacillin. A gentamicin blood sample was taken every day for four days (day </span><span>1 = 1.4 mg/L, day 2 = 2.1 mg/L, day 3 = 2.1 mg/L, day 4 = 1.6 mg/L). The patient’s serum creatinine was 88 </span><span>μmol/L during the four days. The Hartford nomogram was used to estimate the dosage and interval for administration of gentamicin.<br /> </span><span>Conclusion: </span><span>The Hartford nomogram is a valid tool to monitor the once-daily dosing regimen of gentamicin. </span>
Authors and Affiliations
Eman Helal
Keywords
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