Pharmacological effects of <i>harpagophytum procumbens</i> DC [pedaliaceae] secondary root aqueous extract on isolated gastro-intestinal tract muscles of the chick, Guinea-pig and rabbit
Journal Title: African Journal of Traditional, Complementary and Alternative Medicines - Year 2005, Vol 2, Issue 1
Abstract
In an attempt to scientifically appraise the [i]‘healing powers’[/i] and medicinal value of [i]Harpagophytum procumbens[/i] DC [family: Pedaliaceae], and throw some light on the efficacy and safety of the medicinal plant product, we have examined the pharmacological effects of the plant’s secondary root aqueous extract (HPE) on the chick, guinea-pig and rabbit isolated gastro-intestinal smooth muscle preparations. The results of this laboratory animal study indicate that relatively low to high doses of [i]Harpagophytum procumbens[/i] secondary root aqueous extract (HPE, 10–1000 µg/ml) provoked concentration-related, significant (P0.05) increase in the amplitude of the spontaneous, myogenic, rhythmic, pendular contractions of the rabbit duodenal muscle preparations. On the other hand, relatively moderate to high concentrations of the plant’s extract (HPE, 200–1000 µg/ml) always produced initial slight, significant (P
Authors and Affiliations
Ismail Mahomed, Abdon Nsabimana, John Ojewole
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