PHARMACOLOGICAL EVALUATION OF CATHARANTHUS ROSEUS
Journal Title: International Journal of Pharmaceutical Applications - Year 2011, Vol 2, Issue 3
Abstract
The present work is aimed at evaluating antibacterial and antidiabetic activities of whole plant extract of Catharanthus roseus. Dichloromethane: methanol (1:1) extract was used for carrying out in-vitro antibacterial and in-vivo antidiabetic activity. Antibacterial activity was carried out using seven different gram positive and gram negative bacterial strains. The extract was found to have considerable antibacterial action against all bacterial strains. The study on antidiabetic activity involves induction of diabetes to all male Wister albino rats using alloxan monohydrate (80mg/kg body/weight) except control group followed by treatment of diabetic rats with extract (500mg/kg body weight) daily for 14 days. The results were compared with standard drug glibenclamide (5 mg/kg body weight) by measuring glucose levels and body weights of all animals. Glucose level was found to decrease and body weight was increased in extract treated and standard treated groups when compared to diabetic group. The influence of extract on biochemical parameters like total cholesterol, urea, creatinine and alkaline phosphatase were also measured. The results obtained confirms antibacterial and antidiabetic activity of extract and therefore can be used not only against treating infections but also be used in treating diabetes.
Authors and Affiliations
Mohammed Ibrahim , Syeda SughraMehjabeen , Mangamoori Lakshmi Narsu
Keywords
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