PHARMACOVIGILANCE STUDY IN GERIATRIC POPULATION

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PHARMACOVIGILANCE STUDY IN GERIATRIC POPULATION

Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2

Abstract

Objective: Pharmacovigilance is defined as the science and activities concerned with the detection, assessment, understanding and preventionof adverse reactions to medicines. Main goal of pharmacovigilance in geriatric is to improve the safe and rational use of medicines and therebyimproving patient care, health of the society. Pharmacovigilance is particularly concerned with the adverse drug reactions (ADRâ€™s). Hence, a closerpharmacovigilance studies are much needed in the older age group due to polypharmacy, which can cause ADRâ€™s leading to hospital readmissionand the direct and indirect treatment cost to treat the ADRâ€™s. The objective of this study was to assess the prescribing practice and ADRâ€™s ingeriatric patients with two or more comorbid condition during the stay in the hospital and to follow-up on 15th, 30th, 45th, 60th, 75th and 90th dayafter discharge.Methods: The study was conducted in Medicine Department, Kempegowda Institute of Medical Science Hospital and Research Centre, Bengaluru. It isa non-randomized observational prospective study conducted for a period of 6 months, to assess the prescribing pattern and incidence of ADR in thegeriatric population. We made an attempt to assess the incidence of ADRs after discharge from the hospital by doing follow-ups.Results: Among the 50 patients included during the study, 29 (58%) patients were between the age group of 60 and 65 years, out of which 20 werefemale, and 9 were found to be male patients. Out of 50 patients, 40 (37.7%) patients suffered from hypertension, 30 (28.3%) patients had diabetesmellitus. The most commonly used antihypertensive drug was found that 20 (33.8%) patients were on calcium channel blockers which were usedmajorly, in anti-diabetic drugs, insulin was used in 19 (44.1%) patients, followed by 10 (23.2%) patients who were prescribed oral hypoglycemiclike metformin. Number of drugs prescribed per prescription was found that 68% of patients were prescribed with 6-10 drugs. Among the studypopulation, we found the incidence of three mild ADRs during follow-up. During analyzing of prescription, we found totally 122 drug interactions, outof which 83 (68%) were moderate, 30 (25%) were mild and 9 (7%) were found to be severe drug interactions.Conclusion: We observed that monitoring of drugs for ADRs in the geriatric population is mandatory due to their polypharmacy. Follow-up studiesafter discharge for monitoring of ADR will be one step ahead to improve the quality of life. This can reduce the hospital readmission, which can in turnreduce to the economic burden of the patients.Keywords: Pharmacovigilance, Adverse drug reactions, Geriatric, Polypharmacy.Â

Authors and Affiliations

Kiran Nagaraju M, S Manasa, R Manjunath

Keywords

ANTIOXIDANT AND ANTI-INFLAMMATORY EFFECTS OF CURCUMIN CONTRIBUTE INTO ATTENUATION OF ACUTE GENTAMICIN-INDUCED NEPHROTOXICITY IN RATS

Objectives: Nephrotoxicity is a renal-specific situation in which the excretion of toxic metabolites is reduced due to toxic agents and drugs. Gentamicin is an antibiotic belongs to aminoglycoside group which may induce...

EP ID EP605712
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