Phenotypic markers of syndrome of unspecified connective tissue dysplasia in children with acquired myopia
Journal Title: Офтальмологический журнал - Year 2017, Vol 0, Issue 2
Abstract
Purpose: To evaluate the phenotypic markers of the syndrome of unspecified connective tissue dysplasia (SUCTD) in a cohort of children with acquired myopia. Materials and Methods: Two hundred and thirty 7-15-year-old children with acquired myopia of low or moderate degree were involved in the study. They were divided into two age groups, junior (7-11 years; 102 individuals) and senior school children (12-15 years; 128 individuals). Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the risk of myopia progression. Results: The major phenotypic risk factors for developing moderate myopia in children of 7-11 years were prominent venous network of the skin (OR, 7.8; 95% CI, 2.9-20.7; p < 0.05), asthenic habitus (OR, 4.9; 95% CI, 2.1-11.8; p < 0.05), and flat foot (OR, 4.0; 95% CI, 1.7-9.5; p < 0.05), whereas in children of 12-15 years, these factors were moderate or severe connective tissue dysplasia (OR, 7.9; 95% CI, 3.2-19.3; p < 0.05), asthenic habitus (OR, 7.1; 95% CI, 3.2-15.7), cardiac valve prolapse and other minor cardiac anomalies (OR, 6.9; 95% CI, 3.1-15.3; p < 0.05), hypermobility of the joints (OR, 6.1; 95% CI, 2.7-13.6; p < 0.05), postural anomalies and scoliosis (OR, 5.6; 95% CI, 2.5-12.4; p < 0.05), and hyperelasticity of the skin (OR, 5.3; 95% CI, 2.3-12.5; p < 0.05). Conclusions: Low myopic children with a moderate or severe connective tissue dysplasia are at risk for developing moderate myopia. The major SUCTD-related risk factors for developing moderate myopia in children of 7-11 years were prominent venous network of the skin, asthenic habitus, and flat foot, whereas in children of 12-15 years, these factors were asthenic habitus, cardiac valve prolapse and other minor cardiac anomalies, hypermobility of the joints, postural anomalies and scoliosis, and hyperelasticity of the skin.
Authors and Affiliations
T. Tsybulskaya, N. Zavgorodnyaya, E Pashkova
Keywords
Related Articles
- EP ID EP246060
- DOI -
- Views 67
- Downloads 0
Clinical and OCT features of different types and stages of diabetic optic neuropathy
Background: The advent of optical coherence tomography (OCT) has offered new opportunities for differential diagnosis of diabetic optic neuropathy (DON). Purpose: To identify clinical and OCT features of different types...
Ultrastructural changes in the rabbit chorioretinal complex following 577-nm laser photocoagulation
Background: There is no unanimously adopted approach to titrating laser parameters in subthreshold retinal laser photocoagulation without ophthalmoscopically visible fundus changes. Purpose: To investigate the ultrastru...
The effect of high intraocular pressure on enzymatic antioxidant system of uveal tissues in rabbits with experimental allergic uveitis
Background. Determining the influential mechanisms of high intraocular pressure on the development and course of non-infectious anterior uveitis is a relevant but understudied issue which requires a detailed study. Of pa...
Antioxidative status as assessed by enzymatic activity in the tear fluid and by the levels of sulfur-containing protein groups in the blood and tear fluid of myopes before and after treatment with a thiol agent
Background: Myopia remains a leading cause of vision loss and visual disability in Ukraine (75%) and one of the most common ocular disorders worldwide. Most of available biological materials like blood and tear fluid can...
Efficacy assessment of treatment of patients with stage III primary open-angle glaucoma using a combined method (phosphene electrical stimulation and photomyostimulation)
The purpose: to assess the efficacy of a combined method, including phosphene electric stimulation (FES) and photomyostimulation, in treatment of patients with stage III primary open-angle glaucoma (POAG) with compensate...