Phthalic anhydride. Determination in workplace air
Journal Title: Podstawy i Metody Oceny Środowiska Pracy - Year 2016, Vol 32, Issue 1
Abstract
Phthalic anhydride is a crystalline solid. Phthalic anhydride is an important intermediate in thechemical industry. It is harmful, irritating and sensitizing.The aim of this study was to develop a new method for determining concentrations of phthalicanhydride in workplace air in the range from 1/10 to 2 MAC values, in accordance with therequirements of Standard No. EN 482. The study was performed using an liquidchromatograph (Agilent Technologies series 1200) with a diode array detector (DAD). Thedetermination was performed in the reversephase system (mobile phase: acetonitrile:solution of phosphoric acid) using an Ultra C18 column (250 × 4.6 mm with dp = 5 μm) and withprecolumn (10 × 4 mm).The method is based on passing air through a 3,4-dimethoxybenzylamine-coated glass fiberfilter. Samples were extracted with acetonitrile/ammonia and analyzed with HPLC-DAD.The procedure was validated according to Standard No. EN 482. The measuring range was0,1 ÷ 2 mg/m[sup]3[/sup], the limit of detection (LOD) was 9.91 ng/ml (0.000137 mg/m[sup]3[/sup] a 720-L air sample), the limit of quantification (LOQ) was 29.74 ng/ml (0.000413 mg/m[sup]3[/sup] a 720-L air sample), the overall accuracy of the method was 5.31% and the relativetotal uncertainty of the method was 11.63%.The analytical method described in this paper enables selective determination of phthalic anhydride in workplace air in the presence of other compounds at concentrations from 0.1 mg/m³ (1/10 MAC value). The method is precise, accurate and it meets the criteria for proceduresfor measuring chemical agents listed in Standard No. EN 482.The developed method of determining phthalic anhydride has been recorded as an analyticalprocedure (see appendix).
Authors and Affiliations
Agnieszka Woźnica
Keywords
Related Articles
- EP ID EP81622
- DOI -
- Views 115
- Downloads 0
Cisplatin. Documentation of proposed values of occupational exposure limits (OELs)
Cisplatin is a cytostatic used in the treatment of testicular, ovarian, cervix and bladder cancers, squamous cell carcinoma of a head and a neck, small cell and non-small cell lung cancer. For medical staff, it is availa...
Dichlorek cynku. Metoda oznaczania w powietrzu na stanowiskach pracy
Dichlorek cynku jest bardzo dobrze rozpuszczalny w wodzie. Stosowany jest: w procesach galwanicznych, do impregnacji drewna, w przemyśle włókienniczym, w syntezie organicznej i do produkcji materiałów wybuchowych, np. św...
Conditions of using numerical workers’ models while assessing direct hazards related to exposure to electromagnetic field
This article discusses the possibility of using numerical workers’ body models when as-sessing exposure to electromagnetic fields in testing compliance with the requirements of Directive 2013/35/EU. The requirements rel...
Dimethyl phthalate – inhalable fraction. Documentation
Dimethyl phthalate (DMP) is a colorless, oily liquid with a faint aromatic odor.It is used in the chemical industry (manufacture of dyes, varnishes) and cosmetics (perfume, bubble bath, etc.) as a plasticizer (e.g., c...
Fluoride. Determining fluorides in the inhalable and respirable aerosol fraction in the working environment with ion chromatography
A new procedure for the determination of fluo-rides in aerosol fractions in the workplace air has been elaborated. The method is based on a collection of respirable and inhalation fractions of fluorides on methylcellulos...