Phthalic anhydride. Determination in workplace air
Journal Title: Podstawy i Metody Oceny Środowiska Pracy - Year 2016, Vol 32, Issue 1
Abstract
Phthalic anhydride is a crystalline solid. Phthalic anhydride is an important intermediate in thechemical industry. It is harmful, irritating and sensitizing.The aim of this study was to develop a new method for determining concentrations of phthalicanhydride in workplace air in the range from 1/10 to 2 MAC values, in accordance with therequirements of Standard No. EN 482. The study was performed using an liquidchromatograph (Agilent Technologies series 1200) with a diode array detector (DAD). Thedetermination was performed in the reversephase system (mobile phase: acetonitrile:solution of phosphoric acid) using an Ultra C18 column (250 × 4.6 mm with dp = 5 μm) and withprecolumn (10 × 4 mm).The method is based on passing air through a 3,4-dimethoxybenzylamine-coated glass fiberfilter. Samples were extracted with acetonitrile/ammonia and analyzed with HPLC-DAD.The procedure was validated according to Standard No. EN 482. The measuring range was0,1 ÷ 2 mg/m[sup]3[/sup], the limit of detection (LOD) was 9.91 ng/ml (0.000137 mg/m[sup]3[/sup] a 720-L air sample), the limit of quantification (LOQ) was 29.74 ng/ml (0.000413 mg/m[sup]3[/sup] a 720-L air sample), the overall accuracy of the method was 5.31% and the relativetotal uncertainty of the method was 11.63%.The analytical method described in this paper enables selective determination of phthalic anhydride in workplace air in the presence of other compounds at concentrations from 0.1 mg/m³ (1/10 MAC value). The method is precise, accurate and it meets the criteria for proceduresfor measuring chemical agents listed in Standard No. EN 482.The developed method of determining phthalic anhydride has been recorded as an analyticalprocedure (see appendix).
Authors and Affiliations
Agnieszka Woźnica
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