Physical and Biological Evaluation of Cordiarimide B Isomers as Multidrug Compounds
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 2
Abstract
Multidrug compounds are emerging as a new class of therapeutic agents with potent pharmacological activities for a broad spectrum of diseases. In this study, physical stability, plasma stability, cytotoxicity, superoxide anion radical scavenging activity and antimicrobial activity of four isomers (S)-3- amino-1-((R)-2-hydroxy-2-phenylethyl)piperidine-2,6-dione(1), (S)-3-amino-1-((S)-2-hydroxy-2-phenylethyl) piperidine-2,6-dione(2), (R)-3-amino-1-((R)-2-hydroxy-2-phenylethyl)piperidine-2,6-dione(3), (R)-3-amino-1- ((S)-2-hydroxy-2-phenylethyl) piperidine-2,6-dione(4) were comparatively evaluated. The results demonstrated that, the compounds (S)-3-amino-1-((R)-2-hydroxy-2-phenylethyl) piperidine-2,6-dione(1) and (S)-3-amino-1- ((S)-2-hydroxy-2-phenylethyl)piperidine-2,6-dione(2) manifested high physical stability and low cytotoxicity. Further, these two compounds also exhibited good antimicrobial and superoxide anion radical scavenging activities. Data showed that, the compound (R)-3-amino-1-((R)-2-hydroxy-2-phenylethyl) piperidine-2,6- dione(3) is not a suitable drug molecule. Taken together, these results indicate that the compounds (S)-3-amino1-((R)-2-hydroxy-2-phenylethyl)piperidine-2,6-dione(1), (S)-3-amino-1-((S)-2-hydroxy-2-phenylethyl) piperidine- 2,6-dione (2) and (R)-3-amino-1-((S)-2-hydroxy-2-phenylethyl) piperidine-2,6-dione(4) possess multidrug favorable features like solubility, lipophilicity, permeability and plasma stability.
Authors and Affiliations
Jeevan, B. V, Umashankara, M, Shankar . J3 ;, Kumara, M. N, Niranjan Raj
Keywords
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