Physicochemical Characterization and Evaluation of Mucoadhesive Tablets of Omeprazole for Local Action
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 4
Abstract
In the present work, we developed an effective mucoadhesive tablets of omeprazole(Diomeprazole magnesium powder and omeprazole pellets) by direct punch method with excellent mucoadhesive force using three mucoadhesive polymers namely hydroxyl propyl methyl celluloseK4M, sodium carboxy methyl cellulose, carbopol934p and water insoluble polymer ethyl cellulose which can be attached with the intestinal mucosa. Mucoadhesive tablets are coated with respective polymer and prepared them enteric coated tablets by coated with Eudragit L100. Tablets were evaluated in three mediums like 0.1N HCl for 2hr, pH 6.5 phosphate buffer solution for 10hr. and 7.8 phosphate buffer solution for 12hr. Sodium carboxy methyl cellulose showed above 90% release for 10hr. where carbopol934p provided slow release 100% over a period of 12hr. but Ethyl cellulose containing tablets showed less than 68% release and release was diffusion and erosion controlled and followed Zero order kinetics. Thus, the present study concluded that, Carbopol934p containing mucoadhesive tablets of Omeprazole pellets and Di- Omeprazole magnesium powder can be used for local action in the intestine as well as for Oral Controlled Release Drug Delivery.
Authors and Affiliations
Bahadur S , Bhuyan N. R , Chanda. R. , Roy A , Das S , Choudhury A
Keywords
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