Physicochemical Standardization of Siddha Syrup Preparation Madhulai Manappagu

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Physicochemical Standardization of Siddha Syrup Preparation Madhulai Manappagu

Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 5

Abstract

Context: Siddha system of medicine is one of the pioneer systems of medicine practiced in southern part of India particularly in Tamilnadu. The system of medicine also deals with Paediatric diseases in a separate chapter “Balar Vakatam”. Among the diseases of the children, nutritional disorders play a major role. “Pandu Noi” (Anaemia) is one among the nutritional disorders which hinders the growth and development of the children. It is caused by the deficiency of Iron in children. This Iron deficiency of anaemia is the most common nutritional disorder affecting not only the children but also the adult population particularly the pregnant and menstruating women in developing countries like India. In order to treat this disorder in children, safe and easily administrable syrup “Madhulai Manappagu” (A syrup formulation with Punica granatum - Pomegranate juice as a main ingredient) which is in common Siddha practices and explained in the text “Siddha Vaithya Thirattu”, is selected to screen for its physico chemical characteristics as a step to validate it scientifically. Aim: To standardize the herbal syrup preparation Madhulai Manappagu on the basis of qualitative and quantitative methods as per the analytical specifications of syrup/manappagu prescribed by the Protocol testing of ASU drugs by Pharmacopoeial laboratory for Indian Medicines. Materials and Methods: The syrup is prepared as described in the text “Siddha Vaithya Thirattu”. The medicine is subjected to physicochemical and phytochemical analysis, microbial load, aflatoxin assay, sterility test, pesticide residue analysis, heavy metal analysis, Gas chromatography – Mass spectrometry analysis, High Performance Thin Layer Chromatography and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) as per the Pharmacopeial laboratory standards of Indian medicine. Results and Conclusion: The syrup is in liquid form which is reddish brown in colour. It is highly viscous and opalescent with a pleasant odour. The specific gravity of the syrup is 1.2670. The aflatoxin assay revealed that the syrup is free of aflatoxins. The results of analysis for pesticide residue show no traces of pesticides residues in the syrup. The formulation is free of microbial contamination and shows positive for the presence of steroids, alkaloids, flavonoids, tannins, phenols, carbohydrates, glycosides etc. The quantitative analysis of the syrup estimates about 2.80 ± 0.11 mg/gm of flavonoids, 0.632 ± 0.04 mg/gm of alkaloids, 0.37 ± 0.03mg/gm of tannins and 0.97 ± 0.05 mg/gm of phenol. The total ash value is 5.66 ± 1.69%. The heavy metals such as arsenic, lead, mercury, cadmium are below detectable limit. The result Analysis of GC-MS Study of the syrup reveals the presence of 12 prominent peak in which the11th prominent peak reveals the presence of ascorbic acid. This ascorbic acid is essential for the absorption of iron from the intestines and aids in Erythropoiesis. The results of the present study ensures the safety profile of the Madhulai Manappagu – Siddha herbal syrup intended for paediatric usage and indicative of presence of active phytoconstituents that are responsible for its efficacy in treating the Pandu Noi (Iron Deficiency Anaemia) in children.

Authors and Affiliations

Meenakshi Sundaram M, Logamanian M, Banumathi V

Keywords

EP ID EP374954
DOI 10.9790/0853-1705101728.
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