Physiological and biochemical processes in the organisms of rats that were fed with different amounts of germanium citrate
Journal Title: Біологія тварин - Year 2015, Vol 17, Issue 2
Abstract
Organic germanium compounds are characterized by a wide spectrum of effect on the organisms of people and animals and are used as a food supplement to enhance the immunological organism reactivity. However, using of the toxic inorganic forms as precursors for obtaining organic germanium compounds by chemical synthesis indicates the urgency of searching for the alternative ways to get them. This article presents the results of the study of the influence of different amounts of germanium citrate, which was obtained by electric impulse nanotechnology method, onto the physiological processes in rat organismto determine the optimal dose. The germanium citrate solutions with the concentrations of 10, 200, and 300 µg of Ge/L were used in the study. It was determined that feeding with germanium with the concentration of 10 µg of Ge/L did not show significant changes of the studied parameters. While an elevated concentration of hemoglobin, circulating immune complexes, and average weight molecules were observed in the blood of the rats, which were fed with germanium citrate with the concentrations of 200 and 300 µg of Ge/L. Such changes may indicate the immunomodulatory properties of the germanium citrate. Probable decrease in the concentration of the lipid hydroperoxides and TBA-active products in the blood of the animals, which were fed with the germanium citrate with the concentrations of 200 and 300 µg of Ge/L of water, was also found out. More effective physiological influence of the germanium onto the peroxidation processes was noticed in case of feeding its citrate with the concentrations of 200 and 300 µg of Ge/L. So feeding with the germanium citrate, produced with the help of the nanotechnology method, improves the immunological indicators and reduces the intensity of the lipid peroxidation of the infant rats.
Authors and Affiliations
O. P. Dolaychuk, R. S. Fedoruk, I. I. Kovalchuk, S. I. Kropyvka
Keywords
Related Articles
- EP ID EP349737
- DOI 10.15407/animbiol17.02.050
- Views 88
- Downloads 0
Metabolic profile of cows blood after treatment the follicular cysts in different ways
The aim of the study was to determine some biochemical parameters in the blood of cows (Ukrainian black and white dairy breed) with follicular ovarian cyst at the 1st or 2nd lactation after the application of different m...
The effectiveness of irradiation of bull-sire scrotum with incoherent polarized light
The research was conducted to explore the effect of incoherent polarized light emitted by the lamp “Bioptron Compact III” on the general state of bulls-sires, morphological, biochemical parameters of their blood and qual...
Cathepsin B maintenance in the liver of rainbow trout (Oncorhynchus mykiss) throughout virus infection
Biochemical aspects of pathogenicity of infectious pancreatic necrosis virus (IPNV) that is the a causative agent of disease in rainbow trout (Aquabirnavirus of Birnaviridae family), in organism of rainbow trout are prac...
Study of pаthogenic and immunogenic properties of E. coli IBM-1 strains in the development of new immunogenic drugs
In the prevention of colibacillosis in calves some success has been achieved, but the problem is still far from its complete resolution. The results of the study of pathogenic and immunogenic properties of E. coli IBM-1...
The functional activity changes in rat’s neutrophils in experimental collagen arthritis
There were investigated the functional changes in rat neutrophils in experimental collagen arthritis, which is a model of rheumatoid arthritis (RA) in humans. There were examined the absorption capacity of neutrophils in...