Phytochemical Analysis and Antioxidant Property of Selected Medicinal Plants Native to Cambodia
Journal Title: Drug Designing & Intellectual Properties International Journal - Year 2018, Vol 1, Issue 2
Abstract
Cambodian medicinal plants have been used to treat different diseases such as cardiovascular diseases, inflammation, cancers, diabetes and AIDS. This study aimed at conducting the Phytochemical analysis and in vitro antioxidant activities of whole plant of BryophyIIumpinnatum (Lam.) Kurz, barks of Dillenia ovata Wall. ex Hook. f. & Thomson, rhizomes of Drynariafortunei (Kunze ex Mett.) J. Sm. and barks of Lophopetalumwallichii Kurz. native to Cambodia. All the plants were extracted with ethanolby maceration extraction method. The Phytochemical analysis for alkaloids, phenolic compounds, tannins, flavonoids, coumarins, steroids, terpenoids, cardiac glycosides, essential oils, saponins and resins by using the standard methods. The in vitro antioxidant property was evaluated by assessing the DPPH' radical scavenging ability. The preliminary Phytochemical evaluation of these species exhibited that the ethanolic extracts of B. pinnatum (whole plant), D. ovata (barks), D.fortunei (rhizomes) and L.waIIichii (barks) contain alkaloids, phenolic compounds, tannins, flavonoids, terpenoids, cardiac glycosides, saponins and resins. Moreover, the ethanolic extracts of B. pinnatum whole plant, D. ovata barks, and D.fortunei rhizomes possess coumarins and steroids, and of L.waIIichii barks have essential oils. The in vitro antioxidant activity of the species B. pinnatum whole plant, D. ovata barks, D.fortunei rhizomes and L.waIIichii barks have prominent antioxidant activities. This study suggests the potential source of natural antioxidant in B. pinnatum, D. ovata, D.fortunei and L.waIIichii native to Cambodia. Further research is highly recommended on the isolation of the antioxidant compounds from these species. Reactive Oxygen Species (ROS) or free radicals are unstable intermediates formed from molecules via the breakage of a chemical bond such that each fragment keeps one electron, via cleavage of a radical to give another radical and, also via redox reactions [1] . The ROS are categorized into oxygen-centered radicals and oxygen-centered non-radicals. The oxygen-centered radicals include superoxide anion (oO2_), hydroxyl radical (oOH), alkoxyl radical (RO^) and peroxyl radical (ROO^), and nitrogen species. The oxygen-centered non-radicals are hydrogen peroxide (H2O2) and singlet oxygen (1O2), hypochlorous acid (HClO) and ozone (O3) [2] . Free radicals are also generated either from normal essential metabolic processes in the human body or from external sources such as exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals causing oxidative stress which is able to adversely alter lipids, protein and DNA triggering various human complications such as cancers, atherosclerosis, neurodegenerative diseases, diabetes, age-related eye disease and Parkinson’s disease [3].
Authors and Affiliations
Samell Keo, Sonita Leang, Chanseiha Ny, Sokhany Lim, Kosalvorlak Chean, Huykhim Ung, Juthamart Maneenet, Yaowared Chulikhit, Sin Chea
Keywords
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- EP ID EP585929
- DOI 10.32474/DDIPIJ.2018.01.000109
- Views 189
- Downloads 0
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