PHYTOCHEMICAL ANALYSIS AND CARDIOPROTECTIVE ACTIVITY OF PLUMBAGO ZEYLANICA LINN IN ISOPROTERENOL PROVOKED OXIDATIVE MYOCARDIAL INJURY IN ALBINO WISTAR RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 9
Abstract
The phytochemical investigation of Plumbago zeylanica is done by using chemical tests and also by using analytical instruments like Fourier transform-Infra red spectroscopy and confirmed the presence of flavonoids. Isoproterenol a β- adrenergic agonist is used to induce the myocardial injury as it causes the generation of reactive oxygen free radicals and results in the necrosis of cardiac myocites. The Myocardial infarction is confirmed by serum analysis for Lipid profile, Cardiac biomarkers and the oxidative markers are also estimated in the tissue homogenate, the cardio protective effect of Plumbago zeylanica is confirmed by analysis of the above parameters and concluded that the hydro alcoholic extract of Plumbago zeylanica has the cardio protective effect.
Authors and Affiliations
venkata Karre siva , kiran Tallapudi , N. Chidambranathan, Vinodth Prabhu
Keywords
Related Articles
- EP ID EP92828
- DOI -
- Views 96
- Downloads 0
DIFFERENT ANIMAL MODELS FOR DRUGS WITH POTENTIAL ANTIDIABETIC PROPERTIES
The increasing worldwide incidence of diabetes mellitus in adults constitutes a global public health burden. It is predicted that by 2030, largest number of people with diabetes. Although medicinal plants have been histo...
ANTIMICROBIAL SCREENING OF SOME NOVEL SUBSTITUTED CHALCONE DERIVATIVES
Chalcone is an aromatic ketone that forms the central core for the variety of important biological compounds, which are collectively known as chalcones. The derivatives of chalcones with an annular nitrogen atom in the p...
AMOMUM SUBULATUM ROXB: AN OVERVIEW IN ALL ASPECTS
Amomum subulatum Roxb. (Family Zingiberaceae) is commonly known as ‘Badi Elaichi’ or Greater Cardamom. The present study deals with the an overview in all aspects of Amomum subulatum Roxb. It contain Protein 6.0%, Starch...
FLUORIDE TOXICITY – A HARSH REALITY
There are many incidents of fluoride toxicity whether it is acute or chronic. Fluoride toxicity is an environmental hazard which arises from the upper layers of geological crust and is dissolved in water. Prolonged drink...
EVALUATION OF ANTI-INFLAMMATORY ACTIVITY AND ANALGESIC EFFECT OF ALOE VERA LEAF EXTRACT IN RATS
Clinical evaluation of analgesic and anti-inflammatory drugs envisages the development of side effects that makes efficacy of a drug arguable. Alternatively, indigenous drug with fewer side effects is the major thrust ar...