Phytochemical and antipyretic potential of ethanolic leaf extract of Heliotropium indicum L.
Journal Title: Journal of Applied Pharmaceutical Research - Year 2016, Vol 4, Issue 2
Abstract
In the present study, the ethanolic leaf extract of Heliotropium indicum L (H. indicum L) was investigated for phytochemical screening and antipyretic activity in rats using Brewer's yeast induced Pyrexia. The leaves of H. indicum were collected from different part of Assam and cut into small pieces and shade dried. The dried powdered leaves (100 gm) were extracted in a Soxhlet apparatus by using 95% ethanol. Phytochemical screening has been done by standard procedure and showed the presence of alkaloids, glycoside, carbohydrate, phytosterol, flavonoids and saponins and absence of fixed oil and gums-mucilage. Albino rats weighing (200-250g) were taken for the experiment divided into four groups of six animals each. Group 1 received 3% aqueous suspension of gum Acacia (1ml/200g) as vehicle orally, group 2 and group 3 received ethanolic leaf extract of H. indicum 250 and 500 mg/kg with 3% aqueous suspension of gum Acacia orally and the group 4 served as standard received paracetamol 25 mg/kg with 3% aqueous suspension of gum Acacia orally. The subcutaneous injection of yeast suspension markedly elevated the rectal temperature after 18h of administration. Treatment with H. indicum extract at a dose of 250, 500 mg/kg decreased the rectal temperature of the rats in dose dependent manner. This effect was maximal at dose of 500 mg/kg and it caused significant lowering of body temperature (P< 0.01) up to 4 hour after its administration. The antipyretic effect started as early as 1h and the effect was maintained for 4h, after its administration. Both the standard drug paracetamol 25mg/kg and tested drug H. indicum extract were significantly reduced the yeast elevated rectal temperature, at 2nd, 3rd and 4th hour compared to control group
Authors and Affiliations
Mrinmoy Dey, Biblab Kumar Dey
Keywords
Related Articles
- EP ID EP214893
- DOI -
- Views 169
- Downloads 0
Solubility enhancement of biperidine hcl by complexation with hydroxypropyl β-cyclodextrin
Oral route is the simplest and easiest way of drug administration, because of the greater stability, lesser bulk, and cheap cost of production, accurate dosage and easy process, solid oral dosage forms have several advan...
A review on the pros and cons of online pharmacies
Buying medicines online is common practice across the globe these days. This is because buyers are preferring to order for medicines through a click of a button rather than taking a trip to a drug store. Such online webs...
Pharmacological screening of Alsotonia scholaris
A large number of medicinal plants are claimed to possess anthelmintic property in traditional systems of medicine and are also utilize by ethnic groups worldwide. The development of anthelmintic resistance and the high...
Synthesis and antifungal activity screening of some novel 7–substituted –2–hydroxy–quinoline schiff bases
With an objective of synthesizing some novel, potent and broad spectrum antifungal activity having compounds, here some novel quinoline derivatives are reported. Initially 7-substituted-2-cholro-3-formylquinolines were p...
Smart ungual biopenetrant from the roots of Beta vulgaris
The main objective of the current research was to isolate biopenetrant from Beta vulgaris and formulate bioadhesive layers loaded with terbinafine using this biopenetrant for delivery through nail. Form the preparation o...