Synthesis and antifungal activity screening of some novel 7–substituted –2–hydroxy–quinoline schiff bases
Journal Title: Journal of Applied Pharmaceutical Research - Year 2016, Vol 4, Issue 4
Abstract
With an objective of synthesizing some novel, potent and broad spectrum antifungal activity having compounds, here some novel quinoline derivatives are reported. Initially 7-substituted-2-cholro-3-formylquinolines were prepared using well known Vilsemeir-Hack reagent method. These on microwave irradiation with 4M HCl yielded 7-substituted-2-hydroxy quinoline-3-carbaldehydes I(a, b), which on further treatment with different substituted hydrazides yielded the novel Schiff bases of quinoline II(a-f). The structure of all newly synthesized compounds was confirmed by spectral study such as IR, 1H NMR, 13C NMR and mass spectroscopy. All the synthesized compounds were screened for in-vitro antifungal activity by two fold serial dilution method using fluconazole as the standard drug. Compounds II a, II b and II d showed significant antioxidant activity.
Authors and Affiliations
M. R. Pradeep Kumar
Keywords
Related Articles
- EP ID EP213918
- DOI -
- Views 225
- Downloads 0
An overview of tuberculosis chemotherapy – a literature review
Tuberculosis (TB) is a major global health threat. The emergence of human immunodeficiency virus (HIV) and also multi drug resistant (MDR) and extremely drug resistant (XDR)-TB poses a vital challenge to the control of t...
Concept of "AMA DOSHA" WSR to free radicals
Ama is considered as root cause of all diseases in the body. It has tremendous capacity to vitiate the Doshas and disturbing the homeostasis (Dhatusamya). Ama is the result of improper digestion or partially digestion...
Pharmacognostic Evaluation and Physico-chemical Analysis of Ulmus wallichiana Planch.
The plant Ulmus wallichiana Planch. (Family: Ulmaceae) is found in Himalayan regions from Afghanistan to West Nepal. In India, it is found in Kumaun and Garhwal hills of Uttarakhand (India), locally known as Chamarmou. B...
Phytochemical and antipyretic potential of ethanolic leaf extract of Heliotropium indicum L.
In the present study, the ethanolic leaf extract of Heliotropium indicum L (H. indicum L) was investigated for phytochemical screening and antipyretic activity in rats using Brewer's yeast induced Pyrexia. The leaves of...
A validated reverse phase HPLC method for the simultaneous estimation of clopidogrel bisulfate and rivaroxaban in pharmaceutical application
A simple, sensitive and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Clopidogrel bisulfate and rivaroxaban in pharmaceutical dosage forms. The...