PHYTOCHEMICAL AND BIOLOGICAL STUDIES ON PERSICARIA SALICIFOLIA BROUSS. EX WILLD GROWING IN EGYPT
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2016, Vol 7, Issue 8
Abstract
The phytochemical investigation of Persicaria salicifolia Brouss. ex Willd herb resulted in isolation of trans phytol, β-sitosterol, β-sitosterol-3-O--D-glucoside, luteolin, quercetin, quercitrin, hyperoside and rutin. The compounds were isolated using different chromatographic techniques. The isolated compounds were identified using different spectroscopic techniques including UV, IR, MS, 1HNMR and 13CNMR.The antitumor effect of total ethanolic extract of Persicaria salicifolia herb against solid Ehrlich carcinoma (SEC) was examined and the results revealed that the extract has strong antitumor activity. In vitro cytotoxic assay against human breast carcinoma (MCF-7) and prostate carcinoma (PC3) cell lines was carried out using different fractions of alcoholic extract. Methylene chloride and ethyl acetate fractions exhibited the highest activity against breast carcinoma, while petroleum ether extract exhibited the highest activity against prostate carcinoma cell line. Phytol, luteolin and quercitrin were isolated for the first time from Persicaria salicifolia Brouss. ex Willd.
Authors and Affiliations
Rania M. El-Anwar, Abdel-Rahim S. Ibrahim, Kamilia A. Abo El-Seoud, Amal M. Kabbash
Keywords
Related Articles
- EP ID EP154396
- DOI 10.7897/2230-8407.07889
- Views 105
- Downloads 0
EVALUATION OF ANTI-NEPHROLITHIATIC ACTIVITY OF ETHANOLIC LEAF EXTRACT OF MORUS ALBA L. IN ANIMAL MODELS
Kidney stone is a common painful condition of multifactorial etiopathogenesis, and calcium oxalate (CaOx) is the commonest component of stone. The effect of the ethanolic leaf extract of Morus alba L. against Calculi-Pro...
INVESTIGATION ON ANTIMICROBIAL ACTIVITY OF BIOSURFACTANT PRODUCED BY PSEUDOMONAS FLUORESCENS ISOLATED FROM MANGROVE ECOSYSTEM
The aim of this present study is to investigate the antimicrobial activity of rhamnolipid biosurfactant produced by Pseudomonas fluorescens MFS03 isolated from mangrove forest soil using groundnut oil cake as subst...
DETERMINE THE EFFICACY OF CARBOPLATIN WITH VITAMIN C IN DALTON'S LYMPHOMA TUMOR IN MICE MODEL
Carboplatin, a platinum-containing anticancer drug treatment caused a significant increase in the life span of ascites Dalton’s lymphoma tumor bearing mice. However, as compared to carboplatin alone, combination treatmen...
ISOLATION, PURIFICATION AND CHARACTERIZATION OF ACTIVE COMPOUND FROM ANDROGRAPHIS PANICULATA L AND PHYLLANTHUS AMARUS L AND TESTING THE ANTI-VENOM ACTIVITY OF THE DI-HERBAL EXTRACT BY IN-VITRO AND IN-VIVO STUDIES
The mortality associated with snake bites is a serious medical, social and economic problem in many countries and about 35,000 to 50,000 people reportedly die of snakebites in India; hence in this study an attempt has be...
STUDY OF STANDARD OPERATING PROCEDURE OF NAAG BHASMA IN RELATION TO ITS PHYSICO-CHEMICAL PROPERTIES
Standard operating procedures (SOPs) should to be designed, implemented and set for all Ayurvedic drugs one by one for globalization Ayurveda. In this study, an attempt has been made to introduce SOP for preparation of N...