PHYTOCHEMICAL AND BIOLOGICAL STUDIES ON PERSICARIA SALICIFOLIA BROUSS. EX WILLD GROWING IN EGYPT
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2016, Vol 7, Issue 8
Abstract
The phytochemical investigation of Persicaria salicifolia Brouss. ex Willd herb resulted in isolation of trans phytol, β-sitosterol, β-sitosterol-3-O--D-glucoside, luteolin, quercetin, quercitrin, hyperoside and rutin. The compounds were isolated using different chromatographic techniques. The isolated compounds were identified using different spectroscopic techniques including UV, IR, MS, 1HNMR and 13CNMR.The antitumor effect of total ethanolic extract of Persicaria salicifolia herb against solid Ehrlich carcinoma (SEC) was examined and the results revealed that the extract has strong antitumor activity. In vitro cytotoxic assay against human breast carcinoma (MCF-7) and prostate carcinoma (PC3) cell lines was carried out using different fractions of alcoholic extract. Methylene chloride and ethyl acetate fractions exhibited the highest activity against breast carcinoma, while petroleum ether extract exhibited the highest activity against prostate carcinoma cell line. Phytol, luteolin and quercitrin were isolated for the first time from Persicaria salicifolia Brouss. ex Willd.
Authors and Affiliations
Rania M. El-Anwar, Abdel-Rahim S. Ibrahim, Kamilia A. Abo El-Seoud, Amal M. Kabbash
Keywords
Related Articles
- EP ID EP154396
- DOI 10.7897/2230-8407.07889
- Views 69
- Downloads 0
ANTINOCICEPTIVE ACTIVITY OF COLD WATER EXTRACT OF DESMODIUM TRIFLORUM IN RATS
The aim of this study was to examine antinociceptive potential of cold water extract (CWE) of Desmodium triflorum (Family: Fabaceae / Leguminosae) plant. One of four doses of CWE (dose 4000 mg/ml, 2000 mg/ml and 1000 mg...
DEVELOPMENT AND IN VITRO EVALUATION OF MOUTH DISSOLVING FILMS OF CAPTOPRIL
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme(ACE), the enzyme responsible for the conversion of angiotensin I (AT I) to angiotensinII (AT II). Captoprilmaybeusedinthetreatmentofhypertensi...
FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF SERTACONAZOLE NITRATE
The present work was designed to develop suitable transdermal matrix patch of sertaconazole nitrate, which is of the imidazole class used for antifungal medication, using Ethyl cellulose (EC), Po...
PRODUCTION AND CHARACTERIZATION OF ANTIBIOTICS FROM SOIL-ISOLATED ACTINOMYCETES
In the present study, the soil samples were collected from various places in the Coimbatore, near drainage, mud and coloured soil where there were no plants around. Actinomycetes strains were isolated in specific medium...
PRELIMINARY PHYTOCHEMICAL SCREENING AND ANTIMICROBIAL PROPERTIES OF PLEUROTUS FLORIDA AND PLEUROTUS EOUS AGAINST SOME HUMAN PATHOGENS: A COMPARATIVE STUDY
In this study, Two Oyster mushrooms, Pleurotus florida and Pleurotus eous which are edible varieties that commonly available in South India were taken to investigate the phytochemical Screening and antimicrobial activity...