PHYTOCHEMICAL COMPOUNDS AND ANTIMICROBIAL PROPERTIES OF HOSPITAL TOO FAR (Cnidoscolus aconitifolius)
Journal Title: Advance Research Journal of Multidisciplinary Discoveries - Year 2018, Vol 29, Issue 29
Abstract
This study was carried out to determine the phytochemical and antimicrobial properties of Cnidoscolus aconitifolius (hospital too far) leaves. The plant leaves were obtained from area gardens. The useful components of the leaves were extracted with distilled water (aqueous) and methanol. The phytochemical components both qualitative and quantitative were determined and their activities tested against some pathogenic bacteria. The results of the qualitative phytochemical screening revealed the presence of saponin, alkaloids, glycosides, polyphenols flavonoids, reducing compounds and trace tannins. Phlobatanins, anthraquinones and hydroxymethyl anthraquinones were absent. Further, quantitative phytochemical analysis in (mg/100g) revealed that tannins, saponin, alkaloids, glycosides, polyphenols flavonoids and reducing compounds contain 0.21±0.02, 1.20±0.1, 2.50±0.1, 2.44±0.01, 9.18±0.1. 3.50±0.1, and 4.60±0.02 respectively.It was observed that polyphenols had the highest quantity of 9.18 and tannin the lowest quantity 0.21mg/100g. The screening of Cnidoscolus aconitifolius leaf extracts against some pathogenic bacteria showed some positive antibacterial activity against the selected pathogens. The antimicrobial activities against the pathogenic test organisms ranged from 12.0mm to 17.0mm zones of inhibition at 5g/ml of the aqueous extract for S. aureus and E. coli. At 10g/ml of the aqueous extract, the inhibition zones ranged from20.5mm to 26.0 for S. typhi and P. aeruginosa. For the ethanol extract at 5g/ml, the zones of inhibition were 17.0mm, 18.0mm, 20.0mm, 21.0mm, 22.0mm, and 23.0mm for S. aureus, P. aeruginosa, K. pneumonia, S. typhi, E. coli and S. pyogenes respectively. At 10g/ml ethanol extract, the zones of inhibiyion were 27.5mm, 28.0mm, 28.5mm, 29.0mm, 30.0mm and 31.0mm for E. coli, S. aureus, K. pneumonia, P. aeruginosa, S. typhi and S pyogenes respectively. All the extracts showed more effectiveness as compared to Streptomycin and Septrin and compete favorably with Ciprofloxacin and Ofloxacin. Hospital too far has the potential therefore based on the results to be used to combat most of the diseases caused by the tested pathogens.
Authors and Affiliations
Lennox, J. A, John, G. E, Asitok, A
Keywords
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