PHYTOCHEMICAL INVESTIGATION AND ANTHELMINTIC ACTIVITY OF CELOSIA CRISTATA LEAF EXTRACTS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
Development of anthelmintics from medicinal plants might be served as an alternative source for the conventional anthelmintic drugs. The present study was attempted to assess the possible anthelmintic activity for chloroform, methanol and aqueous extract of Celosia cristata leaves. Two different concentrations (100 mg/ml and 200 mg/ml) of these extracts were used to determine the paralysis and mortality of earthworms, Pheretima posthuma and the results were compared with standard anthelmintic drug, albendazole (100 mg/ml and 200 mg/ml). Worms placed in both aqueous and methanol extracts of C. cristata showed significant paralysis and leads mortality in dose dependent manner. Chloroform extract showed no significant activity against the worms. The results revealed that the aqueous extract had higher significant anthelmintic activity than methanol extract. The preliminary phytochemical analysis on the extracts showed the presence of alkaloids, flavanoids, triterpenoids, phenolic compounds and tannins, which might be responsible for the anthelmintic activity.
Authors and Affiliations
Rubini Danabalan , Sudhahar Dharmalingam , Anandarajagopal Kalusalingam
Keywords
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