PHYTOCHEMICAL INVESTIGATION AND ANTHELMINTIC ACTIVITY OF CELOSIA CRISTATA LEAF EXTRACTS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
Development of anthelmintics from medicinal plants might be served as an alternative source for the conventional anthelmintic drugs. The present study was attempted to assess the possible anthelmintic activity for chloroform, methanol and aqueous extract of Celosia cristata leaves. Two different concentrations (100 mg/ml and 200 mg/ml) of these extracts were used to determine the paralysis and mortality of earthworms, Pheretima posthuma and the results were compared with standard anthelmintic drug, albendazole (100 mg/ml and 200 mg/ml). Worms placed in both aqueous and methanol extracts of C. cristata showed significant paralysis and leads mortality in dose dependent manner. Chloroform extract showed no significant activity against the worms. The results revealed that the aqueous extract had higher significant anthelmintic activity than methanol extract. The preliminary phytochemical analysis on the extracts showed the presence of alkaloids, flavanoids, triterpenoids, phenolic compounds and tannins, which might be responsible for the anthelmintic activity.
Authors and Affiliations
Rubini Danabalan , Sudhahar Dharmalingam , Anandarajagopal Kalusalingam
Keywords
Related Articles
- EP ID EP108769
- DOI -
- Views 115
- Downloads 0
MICROBIOLOGICAL EXAMINATION OF SCLICED FRUITS SOLD IN MINNA METROPOLIS
Fresh cut fruits processed by peeling, slicing or trimming with or without further processing or cooking before consumption. Fresh cut fruits collected from different stationary vendors and hawkers in Minna metropolis we...
ANTIHYPERLIPIDEMIC ACTIVITY OF DIVYA METHIPACHAK AGAINST TRITON X-100 INDUCED HYPERLIPIDEMIA IN RATS
The present study was designed to evaluate the anti-hyperlipidemic activity of Divya Methipachak a polyherbal formulation against triton induced hyperlipidemia in rats. Hyperlipidemia was induced by Triton X-100 (100 mg/...
A HOT WAY LEADING TO HEALTHY STAY
Green Chilli is the life and soul of all delicious Indian dishes. It has been cultivated for thousands of years. Green Chilli is a fruit of the flowering plant Capsicum frutescens. Unripe fruits are green in color. On ri...
TRANSFEROSOME: THE DRUG LOADED ULTRADEFORMABLE VESICLES FOR TRANSDERMAL DRUG DELIVERY
Now a days, The novel drug delivery system is creating a new interest in development of drug deliveries. Vesicular drug delivery system in also a part of this novel drug delivery system which is designed according to the...
SOLUBILITY IMPROVEMENT OF POORLY WATER SOLUBLE DRUG FENOFIBRATE BY SOLID DISPERSION IN POLYETHYLENE GLYCOL-HYDROXY PROPYLE METHYLE CELLULOSE MIXTURE
The objective of this study is to formulate solid dispersion of fenofibrate by hot melt extrusion method for improving aqueous solubility. Different formulation was prepared mixing microcrystalline drug, Poly Ethylene Gl...