PHYTOCHEMICAL INVESTIGATION AND IN VITRO ANTIFUNGAL ACTIVITY OF ESSENTIAL OIL FROM THE RHIZOME OF BERGENIA STRACHEYI (HOOK.F. & THOMSON) ENGL.
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 1
Abstract
The essential oil from the rhizome of Bergenia stracheyi (Hook.f. & Thomson) Engl. growing in the Himalayan region of Jammu & Kashmir is found rich in oxygenated sesquiterpenoids (43.06%) and higher oxygenated hydrocarbons (29.83%). Sesquiterpenoids (0.46%) and monoterpenoids (0.24%) were almost absent in the oil. Among oxygenated sesquiterpenoids Cadinene <14-hydroxy-δ-> (38.36%) and Khusinol (2.06%) were the main components. The higher hydrocarbons and their derivatives include n-Hexadecanoic acid (10.60%), cis-9-hexadecenoic acid (4.46%), Linoleic acid (2.85%), Octacosane (2.52%), Cetanol (2.26%), Oleic acid (2.14%), Nonacosane (1.86%), n-Pentacosane (1.66%) and Untriacontane (1.48%). The oxygenated monoterpenoids include α-Terpineol (1.10%) as main constituent. The oil also contains m-xylene (11.27%) as the major lower hydrocarbon. The decoction of rhizome from Bergenia stracheyi are used in folk lore medicines in Jammu & Kashmir. The oil from the rhizome has shown moderate antifungal activity with 100% mycelia growth inhibition against S. sclerotiorum and A. tenuis at a concentration of 2000µg/ml and 3000µg/ml respectively. However C. graminicola and F. oxysporum were found less susceptible to this oil. The IC50 values showed a range from 802.7µg/ml to 1615.4µg/ml as compared to standard fungicides with IC50 values ranging from 36.8µg/ml - 78.6µg/ml. The spore germination inhibition test has revealed this oil as a moderate inhibitor with IC50 values 899.6µg/ml, 545.2µg/ml and 2014.7µg/ml for A. tenuis, C. graminicola and F. oxysporum spores respectively.
Authors and Affiliations
Pawan Kumar
Keywords
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- EP ID EP294645
- DOI 10.22270/jddt.v7i1.1365
- Views 72
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