Phytochemical profiling, antimicrobial and cytotoxicity studies of methanolic extracts from Ruta graveolens
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 5
Abstract
Aim of study: Ruta graveolens is found to have potential value in traditional medicine its components are of great interest in medicinal chemistry. It contains many active principles that act as antioxidants and possess anticancer, antiviral and antimicrobial properties. The present study deals with quantitative and qualitative studies of phytochemicals in Ruta graveolens including GC-MS profiling of the methanolic extracts of stem, root and leaves. The antimicrobial and anticancer activities are also reported. Results: Qualitative and quantitative studies revealed that extracts from different parts of Ruta graveolens showed variation of phytochemical components that included alkaloids, flavonoids, phenols and tannins. GC-MS profiling lead to the identification of more than 160 phytochemicals. The extracts were also found to have microbe inhibiting activities from different regions (stem, root and leaf) and potential cytotoxic activities with a lethal concentration of 62 μg against Hep2 cell lines. Conclusion: The present study has opened avenues in the field of purification of active components of plants. Characterization of these compounds may find potential applications in pharmaceutical and drug industry. Further studies may also aim in the screening of this plant for antiviral activity against HIV and other dreadful diseases.
Authors and Affiliations
Benazir J. F, Suganthi R, Renjini Devi M. R, Suganya K, Monisha K, Nizar Ahamed K. P, Santhi R.
Keywords
Related Articles
- EP ID EP86027
- DOI -
- Views 113
- Downloads 0
RP-HPLC and HPTLC Methods for Determination of Doxofylline in Bulk and Formulations
Two simple, efficient and reproducible methods for the determination of doxofylline in tablets have been developed using reverse phase high performance liquid chromatography and high performance thin layer chromatography...
In vitro anti oxidant activity of leaves extracts of Clerodendrum innerme (L.) GAERTN.
Present study is focused to evaluate the anti oxidant potential of the plant Clerodendrum innerme [Verbenaceae]. The plant is called as “Dedonia” in regional language of Satpuda ranges of Maharashtra state,...
Taste masked, orally disintegrating tablet containing microspheres for immediate release
The purpose of this study was to evaluate the potential of microspheres for taste masking when incorporated intoorally disintegrating tablets. The microspheres were produced by emulsification solvent evaporation method u...
Antibacterial activity of a new Streptomyces sp. SU isolated from Rhizosphere soil
A total of forty Actinomycetes had been isolated from the garden rhizosphere soil. All the isolates were tested against six human pathogenic bacteria viz. Eschrichia coli, Staphylococcus aureus, Klebsiella pnuemoniae, St...
A Selective Reverse Phase HPLC Method For Simultaneous Determination of Perindopril and Indapamide In Solid Dosage Form And Bulk Drug
A rapid and accurate reverse phase high performance liquid chromatographic method has been developed, validated and used for the quantitative determination of Perindopril and Indapamide, from solid dosage forms and bulk...