PHYTOCHEMICAL SCREENING AND ANTIBACTERIAL ACTIVITY STUDY OF SARACA INDICA LEAVES EXTRACT
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 7
Abstract
To know the role of different phytochemicals in relation to the in vitro antibacterial activity of both the ethanolic and methanolic extracts of Saraca indica (Family-Caesalpinaceae), present study was conducted. Following standard methods, phytochemical screening of each extract was performed. For antibacterial activity study, both the extracts were used at 100 µg /ml and 200 µg /ml concentrations. The largest zone of inhibition was produced when ethanolic extract (100 µg/ml and 200 µg/ml) was used against Escherichia coli, whereas the zone was least in case of Staphylococcus aureus. However, methanolic extract (100 µg /ml and 200 µg /ml) gave maximum zone of inhibition against Staphylococcus aureus and it was minimum in case of Bacillus subtilis. Although our extracts were inferior to the positive control (chloramphenicol) as far as zones of inhibition were concerned, the differences between the zones of inhibition produced by the positive control and the extracts against Escherichia coli and Bacillus subtilis were not remarkable .So, it may be noted that both the extracts, even at lower concentration, possess antibacterial activity. From the results of both the studies, it may be concluded that the ethanolic extract showed antibacterial activity was probably due to the presence of alkaloids, tannins, saponins, flavonoids and glycosides. On the other hand, due to different phytochemicals such as steroids, saponins and glycosides, the methanolic extract indicated antibacterial activity. Preliminary phytochemical studies revealed the presence of glycosides and saponins as the phytochemical classes present in both the extracts.
Authors and Affiliations
Sarojini Nayak , Anjulata Sahoo , Chandra Chakraborti
Keywords
Related Articles
- EP ID EP140245
- DOI -
- Views 82
- Downloads 0
SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL SCREENING OF SOME NOVEL BENZIMIDAZOLE DERIVATIVES
The reaction of o-phenylenediamine with anthranillic acid yield compound 2-(1H benzo[d]imidazol-2-yl) aniline (1). The compound (1) was condensed with Chloroacetyl chlorides in the presence of dry benzene to get compound...
IN VITRO COMPARATIVE STUDIES ON SUSCEPTIBILITY PATTERNS OF PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS TO CEFEPIME AND CEFPIROME
The aim of this study was to gather the epidemiological data on the susceptibility patterns of Pseudomonas aeruginosa and staphylococcus aureus against fourth generation cephalosporins (Cefpirome and Cefepime). Total 100...
A STUDY OF SELF MEDICATION AMONG THE PEOPLE OF BHOPAL REGION MADHYA PRADESH, INDIA
The aim of study is to gather information on extent of self medication practice. The outcome of the study will provide data regarding reasons, public awareness and safety aspects of self medication in Bhopal city. It was...
EVALUATION OF HYPOGLYCEMIC AND WOUND HEALING ACTIVITIES OF LANTANA WIGHTIANA WALL. EX GAMBLE LEAVES
Lantana wightiana Wall, a member of Verbenaceae is an unarmed sub shrub, up to 3 m tall. The present study was aimed at evaluating the hypoglycemic and wound healing activities of Lantana wightiana. The leaves were colle...
DESIGN AND CHARACTERIZATION OF TRANSMUCOSAL DRUG DELIVERY SYSTEM OF GLIBENCLAMIDE
Buccal drug delivery has been considered as an alternative to oral route for compounds subjected to degradation in the gastrointestinal tract or hepatic first pass metabolism. Glibenclamide, an oral hypoglycem...